Instituto de Ciencia de Materiales de Sevilla (CSIC-US), c/Américo Vespucio, 49, 41092 Sevilla, Spain.
BIONAND, Andalusian Centre for Nanomedicine and Biotechnology (Junta de Andalucía-Universidad de Málaga), 29590 Málaga, Spain.
Inorg Chem. 2021 Jan 4;60(1):152-160. doi: 10.1021/acs.inorgchem.0c02601. Epub 2020 Nov 17.
We describe a wet chemical method for the synthesis of uniform and well-dispersed dysprosium vanadate (DyVO) and holmium vanadate (HoVO) nanoparticles with an almost spherical shape and a mean size of ∼60 nm and their functionalization with poly(acrylic acid). The transverse magnetic relaxivity of both systems at 9.4 T is analyzed on the basis of magnetic susceptibility and magnetization measurements in order to evaluate their potential for application as high-field MRI contrast agents. In addition, the X-ray attenuation properties of these systems are also studied to determine their capabilities as computed tomography contrast agent. Finally, the colloidal stability under physiological pH conditions and the cytotoxicity of the functionalized NPs are also addressed to assess their suitability for bioimaging applications.
我们描述了一种湿化学方法，用于合成具有几乎球形形状和平均尺寸约为 60nm 的均匀分散的镝钒酸盐（DyVO）和钬钒酸盐（HoVO）纳米粒子，并对其进行了聚丙烯酸功能化。基于在 9.4T 下的磁化率和磁化强度测量，分析了这两个系统的横向磁弛豫率，以评估它们作为高场 MRI 造影剂的应用潜力。此外，还研究了这些系统的 X 射线衰减特性，以确定它们作为计算机断层扫描造影剂的能力。最后，还研究了在生理 pH 条件下的胶体稳定性和功能化 NPs 的细胞毒性，以评估它们在生物成像应用中的适用性。
