Transfusion Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Department of Clinical Haematology, Monash Health, Melbourne, VIC, Australia.
Blood. 2021 Mar 25;137(12):1573-1581. doi: 10.1182/blood.2020008903.
Convalescent plasma (CP) from blood donors with antibodies to severe acute respiratory syndrome coronavirus 2 may benefit patients with COVID-19 by providing immediate passive immunity via transfusion or by being used to manufacture hyperimmune immunoglobulin preparations. Optimal product characteristics (including neutralizing antibody titers), transfusion volume, and administration timing remain to be determined. Preliminary COVID-19 CP safety data are encouraging, but establishing the clinical efficacy of CP requires an ongoing international collaborative effort. Preliminary results from large, high-quality randomized trials have recently started to be reported.
恢复期血浆(CP)来自对严重急性呼吸综合征冠状病毒 2 具有抗体的献血者,通过输血提供即时被动免疫,或用于制造高免疫球蛋白制剂,可能使 COVID-19 患者受益。最佳产品特性(包括中和抗体滴度)、输血量和给药时机仍有待确定。COVID-19 CP 的初步安全性数据令人鼓舞,但要确定 CP 的临床疗效,需要开展一项正在进行的国际合作。最近开始报告来自大型高质量随机试验的初步结果。