Institute of Medical Biochemistry, Centre for Molecular Biology of Inflammation, University of Münster, Von-Esmarch-Strasse 56, 48149 Münster, Germany.
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456, Singapore.
Cells. 2020 Nov 14;9(11):2477. doi: 10.3390/cells9112477.
Discovered over 40 years ago, the annexin proteins were found to be a structurally conserved subgroup of Ca-binding proteins. While the initial research on annexins focused on their signature feature of Ca-dependent binding to membranes, over the years the biennial Annexin conference series has highlighted additional diversity in the functions attributed to the annexin family of proteins. The roles of these proteins now extend from basic science to biomedical research, and are being translated into the clinic. The research on annexins involves a global network of researchers, and the 10th biennial Annexin conference brought together over 80 researchers from ten European countries, USA, Brazil, Singapore, Japan and Australia for 3 days in September 2019. In this conference, the discussions focused on two distinct themes-the role of annexins in cellular organization and in health and disease. The articles published in this Special Issue cover these two main themes discussed at this conference, offering a glimpse into some of the notable findings in the field of annexin biology.
发现于 40 多年前，膜联蛋白被发现是一个结构上保守的 Ca 结合蛋白亚群。虽然最初对膜联蛋白的研究集中在其特征性的 Ca 依赖性结合膜的特性上，但多年来的双年度膜联蛋白会议系列强调了赋予膜联蛋白家族蛋白的功能的额外多样性。这些蛋白质的作用现在从基础科学扩展到生物医学研究，并正在转化为临床应用。膜联蛋白的研究涉及到一个全球性的研究人员网络，第十届双年度膜联蛋白会议于 2019 年 9 月聚集了来自 10 个欧洲国家、美国、巴西、新加坡、日本和澳大利亚的 80 多名研究人员，为期 3 天。在本次会议上，讨论集中在两个不同的主题——膜联蛋白在细胞组织中的作用以及在健康和疾病中的作用。本特刊中发表的文章涵盖了本次会议讨论的这两个主要主题，为我们提供了一些在膜联蛋白生物学领域的显著发现的初步了解。
