Anastasio Albert T, Guisse Ndeye F, Farley Kevin X, Rhee John M
3065Duke University, Durham, NC, USA.
1371Emory University, Atlanta, GA, USA.
Global Spine J. 2022 Jun;12(5):883-889. doi: 10.1177/2192568220968542. Epub 2020 Nov 18.
Retrospective cohort study.
Many patients undergoing posterior spinal fusion (PSF) for scoliosis have concurrent cerebral palsy (CP), which is associated with many medical comorbidities and inherent operative risk. We aimed to quantify the contribution of CP to increased cost, length of stay (LOS), and complication rates in patients with scoliosis undergoing PSF.
Using the National Inpatient Sample database, we collected data regarding patient demographics, hospital characteristics, comorbidities, in-hospital complications, and mortality. Primary outcomes included complications, hospital LOS, and total hospital costs. Multivariate regression models assessed the contribution of CP to in-hospital complications, discharge status, and mortality. Linear regression identified the contribution of a diagnosis of CP on hospital LOS and inflation-adjusted cost.
Cerebral palsy was an independent predictor of several complications. The most striking differences were seen for mortality (odds ratio [OR]: 3.40, < .001), a postoperative requirement for total parenteral nutrition (OR: 3.16, < .001), urinary tract infection (OR: 2.75, < .001), surgical site infection (OR: 2.67, < .001), and pneumonia (2.21, < .001). Patients with CP ultimately cost an additional $13 482 ( < .001) with a 2.07-day greater LOS ( < .001) than patients without CP.
Most complications were seen in higher rates in the CP cohort, with higher cost and LOS in patients with CP versus those with idiopathic scoliosis (IS). Our findings represent important areas of emphasis during preoperative consultations with patients with CP and their families. Extra care in patient selection and multifaceted treatment protocols should continue to be implemented with further investigation on how to mitigate common complications.
回顾性队列研究。
许多因脊柱侧弯接受后路脊柱融合术(PSF)的患者同时患有脑瘫(CP),这与多种合并症及固有的手术风险相关。我们旨在量化脑瘫对接受PSF的脊柱侧弯患者成本增加、住院时间(LOS)及并发症发生率的影响。
利用国家住院样本数据库,我们收集了患者人口统计学、医院特征、合并症、院内并发症及死亡率的数据。主要结局包括并发症、住院LOS及总住院费用。多变量回归模型评估了脑瘫对院内并发症、出院状态及死亡率的影响。线性回归确定了脑瘫诊断对住院LOS及经通胀调整成本的影响。
脑瘫是多种并发症的独立预测因素。在死亡率(比值比[OR]:3.40,P <.001)、术后全胃肠外营养需求(OR:3.16,P <.001)、尿路感染(OR:2.75,P <.001)、手术部位感染(OR:2.67,P <.001)及肺炎(2.21,P <.001)方面观察到最显著差异。与无脑瘫患者相比,脑瘫患者最终多花费13482美元(P <.001),住院时间长2.07天(P <.001)。
在脑瘫队列中大多数并发症发生率更高,与特发性脊柱侧弯(IS)患者相比,脑瘫患者的成本更高且住院时间更长。我们的研究结果代表了在与脑瘫患者及其家属进行术前咨询时需要重点关注的重要领域。应继续在患者选择上格外谨慎并实施多方面治疗方案,同时进一步研究如何减轻常见并发症。