半乳糖凝集素在过敏性炎症性疾病中的作用。

Galectins in allergic inflammatory diseases.

机构信息

School of Chinese Medicine, China Medical University, Taichung, Taiwan; Department of Biotechnology, Asia University, Taichung, Taiwan; Department of Gynecology, China Medical University Hospital, Taichung, Taiwan.

School of Chinese Medicine, China Medical University, Taichung, Taiwan.

出版信息

Mol Aspects Med. 2021 Jun;79:100925. doi: 10.1016/j.mam.2020.100925. Epub 2020 Nov 14.

DOI:10.1016/j.mam.2020.100925

PMID:33203547

Abstract

Allergic inflammatory diseases are a global public health concern affecting millions of people. Although there are several potential hypotheses, details regarding their molecular mechanisms are still ambiguous. Recently, a group of β-galactoside-binding proteins, galectins, have been revealed as important factors in altering allergic chronic inflammatory diseases. In this review, we describe the molecular and cellular basis of how galectins modulate inflammatory reactions. We also provide an overview of clinical features related to galectins. Finally, we discuss the potential issues that might lead to misrepresentation of the exact biological functions of galectins.

摘要

变应性炎症性疾病是一个全球性的公共卫生关注点，影响着数以百万计的人。尽管有几个潜在的假说，但有关其分子机制的细节仍然不清楚。最近，一组β-半乳糖苷结合蛋白，即半乳糖凝集素，已被揭示为改变变应性慢性炎症性疾病的重要因素。在这篇综述中，我们描述了半乳糖凝集素调节炎症反应的分子和细胞基础。我们还概述了与半乳糖凝集素相关的临床特征。最后，我们讨论了可能导致对半乳糖凝集素确切生物学功能的错误表述的潜在问题。