Applied Neuroscience Research Group, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.
Neural Plast. 2020 Nov 5;2020:8836925. doi: 10.1155/2020/8836925. eCollection 2020.
Using multishell diffusion MRI and both tract-based spatial statistics (TBSS) and probabilistic tracking of specific tracts of interest, we evaluated the neural underpinnings of the impact of a six-month dance intervention (DI) on physical fitness and cognitive outcomes in nondemented seniors. The final cohort had 76 nondemented seniors, randomized into DI and control (life as usual) groups. Significant effects were observed between the DI and control groups in physical fitness measures and in attention. We detected associations between improved physical fitness and changes in diffusion tensor imagining (DTI) measures in the whole white matter (WM) skeleton and in the corticospinal tract and the superior longitudinal fascicle despite the fact that no significant differences in changes to the WM microstructure were found between the two groups.
我们采用多壳弥散磁共振成像（multishell diffusion MRI），结合基于束的空间统计学（tract-based spatial statistics，TBSS）和特定感兴趣束的概率追踪，评估了为期六个月的舞蹈干预（dance intervention，DI）对非痴呆老年人身体机能和认知结果的影响的神经基础。最终队列纳入了 76 名非痴呆老年人，随机分为 DI 组和对照组（照常生活）。在身体机能和注意力方面，DI 组和对照组之间存在显著差异。我们发现，尽管两组间脑白质（white matter，WM）微结构的变化无显著差异，但在整个 WM 骨架和皮质脊髓束（corticospinal tract）以及上纵束（superior longitudinal fascicle）的弥散张量成像（diffusion tensor imagining，DTI）指标的改善与身体机能的改善之间存在关联。
