Mitterová Kristína, Lamoš Martin, Mareček Radek, Pupíková Monika, Šimko Patrik, Grmela Roman, Skotáková Alena, Vaculíková Pavlína, Rektorová Irena
Applied Neuroscience Research Group, Central European Institute of Technology, Masaryk University, Brno, Czechia.
Faculty of Medicine, Masaryk University, Brno, Czechia.
Front Aging Neurosci. 2021 Sep 10;13:724094. doi: 10.3389/fnagi.2021.724094. eCollection 2021.
Research on dance interventions (DIs) in the elderly has shown promising benefits to physical and cognitive outcomes. The effect of DIs on resting-state functional connectivity (rs-FC) varies, which is possibly due to individual variability. In this study, we assessed the moderation effects of residual cognitive reserve (CR) on DI-induced changes in dynamic rs-FC and their association on cognitive outcomes. Dynamic rs-FC (rs-dFC) and cognitive functions were evaluated in non-demented elderly subjects before and after a 6-month DI ( = 36) and a control group, referred to as the life-as-usual (LAU) group ( = 32). Using linear mixed models and moderation, we examined the interaction effect of DIs and CR on changes in the dwell time and coverage of rs-dFC. Cognitive reserve was calculated as the residual difference between the observed memory performance and the performance predicted by brain state. Partial correlations accounting for CR evaluated the unique association between changes in rs-dFC and cognition in the DI group. In subjects with lower residual CR, we observed DI-induced increases in dwell time [(58) = -2.14, = 0.036] and coverage [(58) = -2.22, = 0.030] of a rs-dFC state, which was implicated in bottom-up information processing. Increased dwell time was also correlated with a DI-induced improvement in Symbol Search ( = 0.42, = 0.02). In subjects with higher residual CR, we observed a DI-induced increase in coverage [(58) = 2.11, = 0.039] of another rs-dFC state, which was implicated in top-down information processing. The study showed that DIs have a differential and behaviorally relevant effect on dynamic rs-dFC, but these benefits depend on the current CR level.
对老年人舞蹈干预（DIs）的研究表明，其对身体和认知结果具有有益效果。舞蹈干预对静息态功能连接（rs-FC）的影响存在差异，这可能是由于个体差异所致。在本研究中，我们评估了残余认知储备（CR）对舞蹈干预引起的动态rs-FC变化的调节作用及其与认知结果的关联。在36名非痴呆老年人和一个被称为照常生活（LAU）组（n = 32）的对照组中，在为期6个月的舞蹈干预前后评估了动态rs-FC（rs-dFC）和认知功能。使用线性混合模型和调节分析，我们研究了舞蹈干预和认知储备对rs-dFC停留时间和覆盖范围变化的交互作用。认知储备被计算为观察到的记忆表现与脑状态预测表现之间的残余差异。考虑认知储备的偏相关分析评估了舞蹈干预组中rs-dFC变化与认知之间的独特关联。在残余认知储备较低的受试者中，我们观察到舞蹈干预引起的一种与自下而上信息处理相关的rs-dFC状态的停留时间增加[F(1,58) = -2.14, p = 0.036]和覆盖范围增加[F(1,58) = -2.22, p = 0.030]。停留时间增加也与舞蹈干预引起的符号搜索改善相关（r = 0.42, p = 0.02）。在残余认知储备较高的受试者中，我们观察到舞蹈干预引起的另一种与自上而下信息处理相关的rs-dFC状态的覆盖范围增加[F(1,58) = 2.11, p = 0.039]。该研究表明，舞蹈干预对动态rs-dFC具有不同且与行为相关的影响，但这些益处取决于当前的认知储备水平。
