Department of General Surgery, University of Modena and Reggio Emilia, Modena, Italy, 41124, Italy.
Department of Emergency Medicine, University Hospital Modena, Modena, Italy, 41124, Italy.
F1000Res. 2020 May 11;9:343. doi: 10.12688/f1000research.23469.1. eCollection 2020.
Cholecystitis is one of the leading causes of emergency surgical interventions; the occurrence of metastases to the gallbladder is rare and has only been reported in the literature exceptionally. Metastatic breast cancer to the gallbladder is even less frequent; in fact, breast cancer usually metastasizes to bone, lung, lymph nodes, liver and brain. We report the case of an 83-year-old female patient with a previous history of breast surgery with axillary dissection in 1997, followed by adjuvant chemotherapy due to invasive ductal carcinoma of the left breast. The patient was admitted at the emergency department for sepsis and an episode of acute kidney failure, anuria and fever. Right-upper quadrant abdominal pain triggered by food intake and abdominal tenderness was also present, placing the diagnostic suspicion of biliary sepsis due to acute cholecystitis. The histological examination of the surgical specimen highlighted the presence of metastasis from an infiltrating ductal breast carcinoma with positive hormone receptors. We also report here the results of a review of the literature looking at articles describing cases of gallbladder metastasis from breast cancer.
胆囊炎是急诊手术干预的主要原因之一；胆囊转移的发生较为罕见，仅在文献中有过例外报道。转移性乳腺癌转移至胆囊则更为少见；事实上，乳腺癌通常转移至骨骼、肺、淋巴结、肝脏和大脑。我们报告了一例 83 岁女性患者的病例，该患者于 1997 年接受了乳腺癌手术和腋窝清扫术，随后因左乳浸润性导管癌接受了辅助化疗。患者因脓毒症和急性肾衰竭、无尿和发热而入住急诊科。进食时右上腹疼痛和腹部压痛也存在，这使得诊断怀疑为急性胆囊炎引起的胆道败血症。手术标本的组织学检查突出了浸润性导管乳腺癌转移的存在，该乳腺癌具有阳性激素受体。我们还在此处报告了对描述乳腺癌胆囊转移病例的文献综述的结果。
