Affiliated Eye Hospital of Nanchang University, Nanchang Jiangxi, China.
Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan Hubei, China.
Biomed Res Int. 2020 Nov 4;2020:3716859. doi: 10.1155/2020/3716859. eCollection 2020.
The aim of the current meta-analysis was to compare the efficacy of microcatheter-assisted circumferential trabeculotomy (Group 1) with that of conventional trabeculotomy (Group 2) for the treatment of childhood glaucoma.
Published studies were systematically searched via the Web of Science, PubMed, Embase, and Cochrane Library databases. Odds ratios and 95% confidence intervals were calculated for dichotomous variables. Mean ± the standard deviation, mean difference, and 95% confidence intervals were calculated for continuous variables. Heterogeneity was assessed. Random effects modeling and RevMan version 5.30 were used to analyze the data.
Five eligible studies were included in the meta-analysis. Mean postoperative intraocular pressures were significantly lower in Group 1 than in Group 2 at 3 months ( = 0.03), 6 months ( = 0.03), and 12 months ( = 0.007) postoperatively. The complete success rates were higher in Group 1 than in Group 2 at 3 months ( = 0.008), 6 months ( = 0.01), and 12 months ( = 0.004) postoperatively, as were the respective qualified success rates ( = 0.04, = 0.0007, and = 0.001). The pooled estimate indicated lower antiglaucoma medication use in Group 1, especially at 1 month postoperatively ( = 0.003).
Microcatheter-assisted circumferential trabeculotomy resulted in excellent intraocular pressure control, higher success rates, and the utilization of less medication than conventional trabeculotomy for childhood glaucoma. Therefore, microcatheter-assisted circumferential trabeculotomy may be recommended as the initial procedure for the treatment of childhood glaucoma.
本荟萃分析的目的是比较微导管辅助环形小梁切开术（1 组）与传统小梁切开术（2 组）治疗儿童青光眼的疗效。
通过 Web of Science、PubMed、Embase 和 Cochrane Library 数据库系统检索已发表的研究。对二分类变量计算比值比和 95%置信区间。对连续性变量计算均数±标准差、均数差值和 95%置信区间。评估异质性。采用随机效应模型和 RevMan 版本 5.30 分析数据。
荟萃分析纳入 5 项符合条件的研究。术后 3 个月（ = 0.03）、6 个月（ = 0.03）和 12 个月（ = 0.007）时，1 组的平均术后眼压明显低于 2 组。术后 3 个月（ = 0.008）、6 个月（ = 0.01）和 12 个月（ = 0.004）时，1 组的完全成功率高于 2 组，相应的合格率（ = 0.04， = 0.0007， = 0.001）也更高。汇总估计表明，1 组抗青光眼药物的使用率较低，尤其是术后 1 个月时（ = 0.003）。
与传统小梁切开术相比，微导管辅助环形小梁切开术可更好地控制眼压，成功率更高，且术后用药更少，可作为儿童青光眼的初始治疗方法。
