1993年出生队列的第二代，佩洛塔斯（巴西）：目标、设计、初步结果。

Second generation of the 1993 birth cohort, Pelotas (Brazil): Aims, design, preliminary results.

作者信息

Gonçalves Helen, Wehrmeister Fernando C, Assunção Maria C F, Tovo-Rodrigues Luciana, de Oliveira Isabel O, Murray Joseph, Anselmi Luciana, Barros Fernando C, Menezes Ana M B

机构信息

Epidemiology Universidade Federal de Pelotas Pelotas Brazil.

Health and Behavior Universidade Católica de Pelotas Pelotas Brazil.

出版信息

Health Sci Rep. 2020 Nov 10;3(4):e199. doi: 10.1002/hsr2.199. eCollection 2020 Dec.

DOI:10.1002/hsr2.199

PMID:33204847

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7654626/

Abstract

BACKGROUND AND AIMS

Longitudinal cohort studies examining different generations can explain how health problems can be transmitted through genetic and environmental mechanisms and their effects on the health of offspring. This study aimed to present the design and to describe the characteristics of the baseline sample of a second generation cohort.

METHODS

The 93Cohort-II is a dynamic prospective cohort composed of a second generation from the original 1993 Pelotas Birth Cohort (offspring), whose parents had their last follow-up at 22 years old. Biological parents were asked to answer questions addressing the type of birth, general health status, family composition, dietary habits, breastfeeding habits, and child-caregiver(s), among others, and the children's anthropometric measurements were evaluated.

RESULTS

Of 1650 children identified, 1212 were evaluated (response rate, 73.4%), and 21 died before the baseline assessment. The age of the offspring ranged from 0 to 10 years (mean [±SD], 2.9 ± 2.1 years); most children (65.6%) lived with both parents and were born to young mothers and poor families. One-third of the children were breastfed until 6 months of age, one-half were born by cesarean section, 63.9% had used medication in the previous 15 days, 26.4% experienced hospitalization at least once since birth, and 14% had no updated vaccination; asthma/bronchitis (20.4%) and bronchiolitis (13.4%) were the most frequently reported diseases. More than 60% consumed ultra-processed foods, and the prevalence of overweight among those <5 and ≥6 years of age was 10.2% and 18.9%, respectively. The mean total Child Behavior Checklist score was 44.1 ± 23.61 (≥16 months), and the mean intellectual quotient score in children ≥6 years of age was 97.9 ± 15.4.

CONCLUSION

Despite the difficulties in conducting intergenerational cohort studies, the results of the present investigation provide evidence supporting the feasibility of performing these types of studies in middle-income countries.

摘要

背景与目的

对不同代际进行纵向队列研究能够解释健康问题如何通过遗传和环境机制进行传递及其对后代健康的影响。本研究旨在介绍第二代队列的设计并描述其基线样本的特征。

方法

93队列二代是一个动态前瞻性队列，由1993年佩洛塔斯出生队列（后代）的第二代组成，其父母在22岁时进行了最后一次随访。研究要求亲生父母回答有关出生类型、总体健康状况、家庭构成、饮食习惯、母乳喂养习惯及儿童照料者等问题，并对儿童的人体测量数据进行评估。

结果

在确定的1650名儿童中，1212名接受了评估（应答率为73.4%），21名在基线评估前死亡。后代年龄范围为0至10岁（平均[±标准差]，2.9±2.1岁）；大多数儿童（65.6%）与父母双方生活在一起，母亲年轻且家庭贫困。三分之一的儿童母乳喂养至6个月大，一半儿童通过剖宫产出生，63.9%的儿童在过去15天内使用过药物，26.4%的儿童自出生以来至少住院一次，14%的儿童未进行最新的疫苗接种；哮喘/支气管炎（20.4%）和细支气管炎（13.4%）是报告最多的疾病。超过60%的儿童食用超加工食品，5岁以下和6岁及以上儿童超重患病率分别为10.2%和18.9%。儿童行为清单总得分平均为44.1±23.61（≥16个月），6岁及以上儿童平均智商得分为97.9±15.4。