Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Sandra and Edward Meyer Cancer Center, New York, NY, USA.
Cell Rep Med. 2020 May 19;1(2):100020. doi: 10.1016/j.xcrm.2020.100020.
Pancreatic adenocarcinomas (PDACs) are scarcely vascularized and thus virtually insensitive to chemotherapy and immunotherapy. In a recent issue of , Lowe and collaborators have demonstrated that senescence induction by MEK plus CDK4/CDK6 inhibitors favors PDAC revascularization coupled to infiltration by therapeutically actionable CD8 T cells.
胰腺导管腺癌（PDAC）的血管生成极少，因此对化疗和免疫治疗几乎不敏感。在最近一期的 杂志中，Lowe 及其合作者证明，MEK 加 CDK4/CDK6 抑制剂诱导衰老会促进 PDAC 的新生血管形成，并伴有可治疗的 CD8 T 细胞浸润。
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