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铂类化疗通过细胞衰老使卵巢癌微环境发生炎症。

Platinum-based chemotherapy inflames the ovarian carcinoma microenvironment through cellular senescence.

作者信息

Álvarez-Abril Beatriz, García-Martínez Elena, Galluzzi Lorenzo

机构信息

Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.

Department of Hematology and Oncology, Morales Meseguer University Hospital, Murcia, Spain.

出版信息

Oncoimmunology. 2022 Mar 17;11(1):2052411. doi: 10.1080/2162402X.2022.2052411. eCollection 2022.

DOI:10.1080/2162402X.2022.2052411
PMID:35309729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8932912/
Abstract

Epithelial ovarian carcinoma (EOC) is virtually insensitive to immune checkpoint inhibitors (ICIs). Recent findings from an innovative mouse model of EOC demonstrate that senescence induction underlies the increased sensitivity of homologous recombination-defective EOCs to platinum-based chemotherapy as it initiates tumor infiltration by immune effector cells coupled to restored sensitivity to ICIs.

摘要

上皮性卵巢癌（EOC）对免疫检查点抑制剂（ICI）几乎不敏感。最近来自一种创新的EOC小鼠模型的研究结果表明，衰老诱导是同源重组缺陷型EOC对铂类化疗敏感性增加的基础，因为它启动了免疫效应细胞的肿瘤浸润，并恢复了对ICI的敏感性。

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Trends Cancer. 2022 May;8(5):426-444. doi: 10.1016/j.trecan.2022.01.010. Epub 2022 Feb 16.
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Proc Natl Acad Sci U S A. 2022 Feb 1;119(5). doi: 10.1073/pnas.2117754119.
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