Bosch R, Thijssen J H, Duursma S A
Department of Internal Medicine, University Hospital Utrecht, The Netherlands.
J Steroid Biochem. 1987;27(4-6):829-36. doi: 10.1016/0022-4731(87)90156-7.
Dihydrotachysterol2 (DHT2) is a synthetic analogue of vitamin D2. DHT2 is used extensively in the treatment of renal osteodystrophy and hypoparathyroidism. It is equally efficacious as 1 alpha,25-dihydroxyvitamin D3 and 1 alpha-hydroxyvitamin D3. Moreover, it offers interesting therapeutical advantages and it is surprising that until recently little was known of its metabolism and sites of action. This paper deals with studies on the pharmacology of DHT2 in rats. Following the synthesis of [3H]DHT2 and oral administration, evidence was obtained that DHT2 is metabolized extensively; three of the major metabolites could be identified as 25-hydroxy-DHT2, 1 alpha,25- and 1 beta,25-dihydroxy-DHT2.
二氢速甾醇2（DHT2）是维生素D2的一种合成类似物。DHT2广泛用于治疗肾性骨营养不良和甲状旁腺功能减退症。它与1α，25 - 二羟基维生素D3和1α - 羟基维生素D3具有同等疗效。此外，它具有一些有趣的治疗优势，令人惊讶的是，直到最近人们对其代谢和作用部位仍知之甚少。本文论述了对大鼠体内DHT2药理学的研究。在合成[3H]DHT2并口服给药后，有证据表明DHT2会发生广泛代谢；其中三种主要代谢物可鉴定为25 - 羟基 - DHT2、1α，25 - 和1β，25 - 二羟基 - DHT2。
