Urology Departments, Faculty of Medicine, Menoufia University, Shebein Elkom, Egypt.
Pathology Departments, Faculty of Medicine, Menoufia University, Shebein Elkom, Egypt.
J Immunoassay Immunochem. 2021 Mar 4;42(2):188-201. doi: 10.1080/15321819.2020.1844752. Epub 2020 Nov 18.
Urothelial carcinoma is the most common urinary malignancy with a wide proportion of cancer morbidity and mortality. The aim of the present study is to evaluate Ki-67 and p63 immunoexpression and their correlation with grade and stage of bladder urothelial carcinoma. Fifty cases of bladder urothelial carcinoma were investigated and were submitted to immunohistochemical staining for p63 and Ki-67, which were assessed qualitatively and quantitatively. A high percentage of p63 immunoexpression showed a significant association with low-grade tumors ( < .05), while Ki-67 mean percentage of expression was higher in high-grade tumors, advanced stage and multiple tumors compared to low grade, early-stage and single tumors without statistical association. Furthermore, the mean percentage of p63 was higher in urothelial carcinoma with squamous differentiation compared to pure urothelial carcinoma with an absence of statistical significance. P63 could help in the identification of bladder tumors with squamous differentiation since identifying these cases is important regarding prognostic and therapeutic aspects. Ki 67 seems to be associated with features of bladder tumor progression as multiplicity, high grade and advanced stage.
尿路上皮癌是最常见的泌尿系统恶性肿瘤，其发病率和死亡率都很高。本研究旨在评估 Ki-67 和 p63 的免疫表达及其与膀胱尿路上皮癌分级和分期的关系。对 50 例膀胱尿路上皮癌进行了研究，并进行了 p63 和 Ki-67 的免疫组织化学染色，定性和定量评估。高比例的 p63 免疫表达与低级别肿瘤显著相关（<0.05），而 Ki-67 高表达百分比在高级别肿瘤、晚期和多发性肿瘤中高于低级别、早期和单发肿瘤，但无统计学关联。此外，与单纯尿路上皮癌相比，具有鳞化分化的尿路上皮癌中 p63 的平均百分比更高，但无统计学意义。p63 有助于识别具有鳞化分化的膀胱肿瘤，因为这些病例在预后和治疗方面很重要。Ki 67 似乎与肿瘤的多发性、高级别和晚期等进展特征有关。
