新提出的腰围切点作为糖尿病患病风险因素的中心性肥胖标准：来自印度尼西亚基本国家健康调查的证据。
New proposed cut-off of waist circumference for central obesity as risk factor for diabetes mellitus: Evidence from the Indonesian Basic National Health Survey.
机构信息
Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Depok, Indonesia.
Indonesian Society for the Study of Obesity, Jakarta, Indonesia.
出版信息
PLoS One. 2020 Nov 18;15(11):e0242417. doi: 10.1371/journal.pone.0242417. eCollection 2020.
BACKGROUND
Waist circumference (WC) measurement is practical to define central obesity. However, WC cut-off point might be differ based on different race or ethnicity. This study aims to analyze the optimal WC cut-off point to identify T2DM risk among Indonesian population.
METHOD
We analyzed the secondary data of national based cross-sectional study of the Indonesian Basic National Health Research 2013, comprising 24,660 adults aged ≥ 18 years who were assessed for fasting plasma glucose (FPG) and oral glucose tolerance test (OGTT). The new proposed cut-off point for WC was calculated using ROC curve analysis and Youden index. The odds ratio of having T2DM was calculated using logistic regression analysis.
RESULTS
Increased WC was associated with worsening dysglycemia status among men and women (p<0.001). The optimal cut-off point of WC for detecting T2DM from ROC analysis was 76 for men and 80 for women. Based on this WC cut-off point, the odds ratio for having T2DM was 1.64 [95% CI 1.45-1.86, p<0.01] for men and 1.90 [95% CI 1.71-2.11 p<0.01] for women.
CONCLUSION
The newly proposed WC cut-off point of 76 for men and 80 women can be used to screen the risk of T2DM among Indonesian population.
背景
腰围（WC）测量对于定义中心性肥胖很实用。然而，WC 的截断点可能因不同的种族或民族而有所不同。本研究旨在分析最佳 WC 截断点，以确定印度尼西亚人群患 2 型糖尿病（T2DM）的风险。
方法
我们分析了 2013 年印度尼西亚国家基本健康研究的全国性横断面研究的二次数据，该研究纳入了 24660 名年龄≥18 岁的成年人，他们接受了空腹血糖（FPG）和口服葡萄糖耐量试验（OGTT）评估。使用 ROC 曲线分析和 Youden 指数计算 WC 的新建议截断点。使用逻辑回归分析计算 T2DM 的比值比。
结果
WC 的增加与男性和女性的糖代谢恶化状态相关（p<0.001）。ROC 分析确定的 WC 检测 T2DM 的最佳截断点为男性 76cm，女性 80cm。基于此 WC 截断点，男性 T2DM 的比值比为 1.64[95%CI 1.45-1.86，p<0.01]，女性为 1.90[95%CI 1.71-2.11，p<0.01]。
结论
新提出的男性 WC 截断点为 76cm，女性为 80cm，可用于筛查印度尼西亚人群患 T2DM 的风险。
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