Aparato Digestivo, Hospital Universitario San Agustín Aviles, ESPAÑA.
Aparato Digestivo, Hospital Universitario San Agustín, España.
Rev Esp Enferm Dig. 2021 Jan;113(1):77. doi: 10.17235/reed.2020.7120/2020.
Acute pancreatitis is one of the main reasons for hospitalization, with an increasing incidence and associated non-negligible morbidity and mortality. Its most common causes are alcohol and gallstones, and medications are a rare cause. The pathogenesis of acute drug pancreatitis is not yet known exactly and the diagnosis is based on the evident temporal relationship, having excluded the rest of the possible known causes of acute pancreatitis. We present the case of a 71-year-old patient diagnosed with IgG multiple myeloma treated with the Daratumumab, Bortezomib and Dexamethasone regimen. After Bortezomib administration, he developed epigastric pain and elevated pancreatic enzymes in the range of acute pancreatitis. After ruling out common causes, the diagnosis of acute pancreatitis caused by Bortezomib was reached, which presents a favorable rapid evolution after its elimination.
急性胰腺炎是住院的主要原因之一，其发病率不断增加，相关发病率和死亡率不可忽视。其最常见的病因是酒精和胆石症，而药物是罕见的病因。急性药物性胰腺炎的发病机制尚不完全清楚，诊断基于明显的时间关系，并排除了其他已知的急性胰腺炎的可能病因。我们报告了一例 71 岁患者的病例，该患者被诊断为 IgG 多发性骨髓瘤，接受了 Daratumumab、硼替佐米和地塞米松治疗方案。在给予硼替佐米后，他出现了上腹痛和胰腺酶升高，符合急性胰腺炎的范围。在排除常见病因后，诊断为硼替佐米引起的急性胰腺炎，在停用硼替佐米后迅速好转。
