Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Department of Obstetrics and Gynecology, Sheba Medical Center, Ramat-Gan, Israel.
J Matern Fetal Neonatal Med. 2022 Nov;35(21):4199-4207. doi: 10.1080/14767058.2020.1849094. Epub 2020 Nov 18.
To characterize the biometric parameters in ultrasound and brain MRI of fetuses with isolated mega cisterna magna (MCM).
Cross-sectional historical cohort study conducted at a single tertiary medical center between 2011 and 2018. All fetuses underwent US and brain MRI scans. Matching analysis was performed according to gender and gestational age.
The study included a total of 103 fetuses; 44 fetuses with isolated MCM in the study group, and a control group of 59 fetuses with normal CNS. The study group had larger biparietal diameter (BPD) (86 vs. 79.8 mm, = .001) and head circumference (HC) (318 vs. 292 mm, < .001) on ultrasound. On MRI, study group had larger occipitofrontal diameter (OFD) (99 vs. 92 mm, < .001) and BPD (77 vs. 72 mm, < .001). Male fetuses' prevalence was higher in the study group (77.3% vs. 47.5%). After matching 20 fetuses from each group, the study group had larger HC (310.1 versus 300.7 mm, = .029) and OFD (113.4 versus 108.3 mm, = .009) on ultrasound, and larger OFD (97.4 versus 94.6, = .013) on brain MRI.
Isolated MCM may be related to other large fetal CNS biometric measurements in both ultrasound and MRI and might be influenced by fetal gender.
描述孤立性巨大脑脊髓液囊肿（MCM）胎儿的超声和脑 MRI 生物测量参数特征。
这是一项于 2011 年至 2018 年在一家三级医疗中心进行的回顾性队列研究，所有胎儿均接受了超声和脑 MRI 扫描。根据性别和胎龄进行匹配分析。
本研究共纳入 103 例胎儿；研究组 44 例胎儿为孤立性 MCM，对照组 59 例胎儿为正常中枢神经系统。研究组胎儿的超声双顶径（BPD）（86 比 79.8mm， = 0.001）和头围（HC）（318 比 292mm， < 0.001）较大。MRI 上，研究组胎儿的枕额径（OFD）（99 比 92mm， < 0.001）和 BPD（77 比 72mm， < 0.001）较大。研究组男性胎儿的患病率较高（77.3%比 47.5%）。在每组匹配 20 例胎儿后，研究组胎儿的 HC（310.1 比 300.7mm， = 0.029）和 OFD（113.4 比 108.3mm， = 0.009）在超声上较大，而脑 MRI 上的 OFD（97.4 比 94.6， = 0.013）较大。
孤立性 MCM 可能与超声和 MRI 中其他较大的胎儿中枢神经系统生物测量值有关，并且可能受到胎儿性别的影响。
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