Turhan Uğur, Ertaş Sinem
Samsun Training and Research Hospital, Samsun, Turkey.
VKV American Hospital, Women's Health Center, İstanbul, Turkey.
J Matern Fetal Neonatal Med. 2022 May;35(9):1623-1628. doi: 10.1080/14767058.2020.1846706. Epub 2020 Nov 18.
We aimed to explore TREM-1 activation in pregnant women who has preeclampsia through the measurement of its soluble form sTREM.
A prospective cohort study was conducted. Participants were recruited from antenatal clinic between 1 May 2019 and 31 August 2019, and they all provided written informed consent for participation. Women between 18 and 42 years of age who were diagnosed with early or late-onset preeclampsia (LOP) were offered participation if they did not have any known systemic disease (chronic hypertension, diabetes, hypothyroidism, chronic renal-liver diseases, etc.); autoimmune disorders; multiple pregnancies; presence of fetal structural and chromosomal anomalies; placenta previa; cholestasis of pregnancy; preterm delivery; evidence of chronic and active infection. The primary outcome of the study was to assess any difference between groups in terms of the diagnostic value of sTREM level.
A total of 80 patients were enrolled; proven early-onset preeclampsia (EOP) ( = 20), LOP ( = 30), and control ( = 30) groups. There was no significant difference among the groups in terms of age and BMI. Mean gestational age at diagnosis of EOP; 30 ± 1.9 and LOP; 34.7 ± 1.9 weeks gestation. The mean sTREM level was 160.130 ± 1.65 pg/ml in the EOP group, 119.337 ± 2.04 pg/ml in LOP group, and 87.764 ± 1.69 pg/ml in the control group. According to subgroup analysis, sTREM levels were significantly higher in EOP group than control group.
sTREM might be a promising biomarker for early detection of EOP. However, future studies are necessary to confirm this hypothesis.
我们旨在通过测量可溶性髓系细胞触发受体-1（sTREM）来探究子痫前期孕妇中TREM-1的激活情况。
进行了一项前瞻性队列研究。参与者于2019年5月1日至2019年8月31日从产前诊所招募，他们均提供了参与研究的书面知情同意书。年龄在18至42岁之间、被诊断为早发型或晚发型子痫前期（LOP）且无任何已知全身性疾病（慢性高血压、糖尿病、甲状腺功能减退、慢性肝肾疾病等）、自身免疫性疾病、多胎妊娠、胎儿结构和染色体异常、前置胎盘、妊娠期胆汁淤积、早产、慢性和活动性感染证据的女性被邀请参与研究。该研究的主要结局是评估sTREM水平的诊断价值在各组之间的差异。
共纳入80例患者；确诊为早发型子痫前期（EOP）组（n = 20）、LOP组（n = 30）和对照组（n = 30）。各组在年龄和体重指数方面无显著差异。EOP诊断时的平均孕周为30 ± 1.9周，LOP为34.7 ± 1.9孕周。EOP组的平均sTREM水平为160.130 ± 1.65 pg/ml，LOP组为119.337 ± 2.04 pg/ml，对照组为87.764 ± 1.69 pg/ml。根据亚组分析，EOP组的sTREM水平显著高于对照组。
sTREM可能是早期检测EOP的一个有前景的生物标志物。然而,需要进一步的研究来证实这一假设。
