Chabenat C, Moore N, Flipo J L, Barois A, Boismare F, Boucly P
Laboratoire de Pharmacochimie, Faculté de Médecine et Pharmacie de Rouen, Saint-Etienne-du-Rouvray, France.
Pathol Biol (Paris). 1987 Nov;35(9):1235-8.
The diffusion of vancomycin into the cerebro-spinal fluid was studied in 5 healthy dogs. Its appears that vancomycin does diffuse across the blood-brain barrier. Though the concentrations reached in the CSF are low, they are of the same order of magnitude as the minimal inhibitory concentrations of this antibiotic towards the germs usually treated. The usual pharmacokinetic parameters were determined.
在5只健康犬中研究了万古霉素向脑脊液中的扩散情况。看来万古霉素确实能穿过血脑屏障。虽然脑脊液中达到的浓度较低，但与该抗生素对通常治疗的病原菌的最低抑菌浓度处于同一数量级。测定了常规的药代动力学参数。
