Javaheri Nazli, Matin Somaieh, Naghizadeh-Baghi Abbas, Bagheri Abolfazl, Andreasian Ani, Ghobadi Hassan
Department of Internal Medicine, Ardabil University of Medical Sciences School of Medicine, Ardabil, Iran.
Department of Physical Education and Sport Sciences, University of Mohaghegh Ardabili, Ardabil, Iran.
Eurasian J Med. 2020 Oct;52(3):259-264. doi: 10.5152/eurasianjmed.2020.20002.
Chronic obstructive pulmonary disease (COPD) is one of the most prevalent respiratory diseases in the world. There is an impressive relationship between periodontal status and airflow limitation in patients with COPD. Therefore, in this study, we aimed to investigate the periodontal status, its treatment needs, and its relationship with the severity of airway obstruction and quality of life in patients with COPD.
In this case-control study, 36 healthy men (control group) and 35 men afflicted with COPD (case group) were investigated. On the basis of spirometry results and Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria, patients with COPD were further divided into 4 groups. The participants' quality of life was evaluated using COPD Assessment Test (CAT) questionnaire. Thereafter, both groups of participants were referred to a dentistry clinic so that the related specialist could investigate their periodontal health status. The relationship between the periodontal indices and the variables under study including GOLD stage, CAT score, Forced Expiratory Volume in first second and Forced Vital Capacity (FEV1/FVC) ratio, Forced Expiratory Volume in first second (FEV1), and the exacerbation rate were statistically analyzed using independent t-test, one-way analysis of variance, Tukey's test, and Pearson correlation coefficient.
The results revealed that probing pocket depth (PDD), bleeding on probing (BOP), and loss of attachment (LOA) are negatively correlated with FEV1% (r=-0.53, p=0.001), (r=-0.62, p=0.001), and (r=-0.72, p=0.001) as well as FEV1/FVC ratio (r=-0.45, p=0.007), (r=-0.47, p=0.004), and (r=-0.61, p=0.001), respectively. The results showed that PDD, BOP, and LOA are positively correlated with CAT score (r=0.51, p=0.002), (r=0.47, p=0.004), and (r=0.71, p=0.001), respectively.
Periodontal problems are positively associated with COPD severity as determined by GOLD criteria and negatively associated with quality of life of patients with COPD.
慢性阻塞性肺疾病（COPD）是世界上最常见的呼吸系统疾病之一。COPD患者的牙周状况与气流受限之间存在显著关联。因此，在本研究中，我们旨在调查COPD患者的牙周状况、治疗需求及其与气道阻塞严重程度和生活质量的关系。
在这项病例对照研究中，对36名健康男性（对照组）和35名患有COPD的男性（病例组）进行了调查。根据肺功能检查结果和慢性阻塞性肺疾病全球倡议（GOLD）标准，将COPD患者进一步分为4组。使用慢性阻塞性肺疾病评估测试（CAT）问卷评估参与者的生活质量。此后，两组参与者均被转介至牙科诊所，以便相关专科医生调查他们的牙周健康状况。使用独立t检验、单因素方差分析、Tukey检验和Pearson相关系数对牙周指数与包括GOLD分期、CAT评分、第1秒用力呼气容积和用力肺活量（FEV1/FVC）比值、第1秒用力呼气容积（FEV1）以及急性加重率在内的研究变量之间的关系进行统计学分析。
结果显示，探诊深度（PDD）、探诊出血（BOP）和附着丧失（LOA）分别与FEV1%（r=-0.53，p=0.001）、（r=-0.62，p=0.001）和（r=-0.72，p=0.001）以及FEV1/FVC比值（r=-0.45，p=0.007）、（r=-0.47，p=0.004）和（r=-0.61，p=0.001）呈负相关。结果表明，PDD、BOP和LOA分别与CAT评分呈正相关（r=0.51，p=0.002）、（r=0.47，p=0.004）和（r=0.71，p=0.001）。
牙周问题与根据GOLD标准确定的COPD严重程度呈正相关，与COPD患者的生活质量呈负相关。
