Tamiya Hiroyuki, Mitani Akihisa, Abe Masanobu, Nagase Takahide
Division for Health Service Promotion, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
The Department of Respiratory Medicine, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
J Clin Med. 2023 Sep 13;12(18):5935. doi: 10.3390/jcm12185935.
The prevalence of chronic obstructive pulmonary disease (COPD) is increasing worldwide and is currently the third leading cause of death globally. The long-term inhalation of toxic substances, mainly cigarette smoke, deteriorates pulmonary function over time, resulting in the development of COPD in adulthood. Periodontal disease is an inflammatory condition that affects most adults and is caused by the bacteria within dental plaque. These bacteria dissolve the gums around the teeth and the bone that supports them, ultimately leading to tooth loss. Periodontal disease and COPD share common risk factors, such as aging and smoking. Other similarities include local chronic inflammation and links with the onset and progression of systemic diseases such as ischemic heart disease and diabetes mellitus. Understanding whether interventions for periodontal disease improve the disease trajectory of COPD (and vice versa) is important, given our rapidly aging society. This review focuses on the putative relationship between COPD and periodontal disease while exploring current evidence and future research directions.
慢性阻塞性肺疾病（COPD）在全球范围内的患病率正在上升，目前是全球第三大死因。长期吸入有毒物质，主要是香烟烟雾，会随着时间的推移使肺功能恶化，导致成年期患上慢性阻塞性肺疾病。牙周病是一种影响大多数成年人的炎症性疾病，由牙菌斑中的细菌引起。这些细菌会溶解牙齿周围的牙龈以及支撑牙龈的骨骼，最终导致牙齿脱落。牙周病和慢性阻塞性肺疾病有共同的风险因素，如衰老和吸烟。其他相似之处包括局部慢性炎症以及与缺血性心脏病和糖尿病等全身性疾病的发生和发展的关联。鉴于我们社会的快速老龄化，了解针对牙周病的干预措施是否能改善慢性阻塞性肺疾病的疾病进程（反之亦然）非常重要。本综述重点关注慢性阻塞性肺疾病与牙周病之间的假定关系，同时探讨当前证据和未来研究方向。
