Athman Omar Abeid M, Abdel-Bary Amany, Elsaka Rasha O
Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University, Champlion Street, Alazarita, Alexandria 21131, Egypt.
https://orcid.org/0000-0003-4081-8547.
Ecancermedicalscience. 2020 Oct 15;14:1125. doi: 10.3332/ecancer.2020.1125. eCollection 2020.
Thyroid and breast cancer are the most common cancers among young women, which are either synchronous or metachronous, but the association is yet to be elucidated. With the improvement of diagnosis and treatment, there is an increase in breast and thyroid cancer survivors. Hence, attention is shifting towards survivorship. Here, we report the case of a young lady diagnosed with synchronous thyroid and breast cancer who unexpectedly became pregnant during tamoxifen treatment. After a multidisciplinary discussion, endocrine therapy was interrupted and she delivered a healthy baby at term. In conclusion, oncologists should be aware of breast and thyroid cancer co-occurrence and examinations should be conducted together in diagnosis and follow-up. Also, pregnancy is feasible and can be considered after synchronous breast and thyroid cancer diagnosis. Physicians need to emphasise the use of barrier contraceptives to patients undergoing endocrine therapy. However, the optimum timing for pregnancy after breast cancer and the safety of endocrine therapy interruption in hormonal-positive patients should be discussed and managed by a multidisciplinary team.
甲状腺癌和乳腺癌是年轻女性中最常见的癌症，它们可以是同时发生的，也可以是异时发生的，但两者之间的关联尚待阐明。随着诊断和治疗水平的提高，乳腺癌和甲状腺癌幸存者的数量有所增加。因此，关注点正转向生存问题。在此，我们报告一例年轻女性同时被诊断出患有甲状腺癌和乳腺癌的病例，该患者在接受他莫昔芬治疗期间意外怀孕。经过多学科讨论，中断了内分泌治疗，她足月产下一名健康婴儿。总之，肿瘤学家应意识到乳腺癌和甲状腺癌的同时发生，在诊断和随访中应同时进行检查。此外，怀孕是可行的，在同时诊断出乳腺癌和甲状腺癌后可以考虑怀孕。医生需要向接受内分泌治疗的患者强调使用屏障避孕法。然而，乳腺癌后怀孕的最佳时机以及激素阳性患者中断内分泌治疗的安全性，应由多学科团队进行讨论和管理。
