McCracken G H
Department of Pediatrics, University of Texas Health Science Center, Dallas.
Pediatr Infect Dis J. 1987 Oct;6(10):951-3.
Removal of the intravenous line, improvement of attitude and appetite and early discharge from the hospital can be achieved when sequential parenteral-oral antibiotic therapy is used appropriately to treat children with certain moderate to severe infections. Such antibiotic regimens are potentially indicated for suppurative skeletal infections, bacterial endocarditis, pneumonia with or without empyema, pyelonephritis and, perhaps, meningitis. To be effective, serum bactericidal activity against the causative pathogen after oral therapy must be comparable to that achieved after parenteral administration. Patient and parent compliance, adequate absorption and drug interactions are some of the factors that should be considered to assure a successful course of parenteral-oral antibiotic therapy.
当适当使用序贯肠外-口服抗生素疗法治疗某些中度至重度感染的儿童时，可实现静脉输液管拔除、态度和食欲改善以及早期出院。此类抗生素方案可能适用于化脓性骨骼感染、细菌性心内膜炎、伴或不伴脓胸的肺炎、肾盂肾炎，或许还有脑膜炎。为确保有效，口服治疗后针对致病病原体的血清杀菌活性必须与肠外给药后所达到的活性相当。患者及家长的依从性、充分吸收以及药物相互作用是确保肠外-口服抗生素治疗疗程成功应考虑的部分因素。
