儿童遗传性癌症易感性综合征的泌尿生殖系统表现
Genitourinary manifestations of hereditary cancer predisposition syndromes in children.
作者信息
Gillespie Nali Julia, Van Mater David
机构信息
Duke University School of Medicine, Durham, NC, USA.
Division of Pediatric Hematology-Oncology, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA.
出版信息
Transl Androl Urol. 2020 Oct;9(5):2331-2347. doi: 10.21037/tau-2019-pum-09.
Several hereditary cancer predisposition syndromes are associated with genitourinary (GU) manifestations in children. The GU manifestation may be the first symptom of a more global syndrome to arise, which places the pediatric urologist in a unique position to impact the health of the child. Some GU manifestations are pathognomonic for a particular hereditary cancer predisposition syndrome, which can prompt genetic testing and enhanced surveillance for other features of the condition. In other cases, knowledge of an underlying hereditary cancer predisposition syndrome alters treatment decisions. This review focuses on hereditary cancer predisposition syndromes that impact the GU tract and are likely to be seen by a pediatric urologist.
几种遗传性癌症易感性综合征与儿童泌尿生殖系统（GU）表现相关。泌尿生殖系统表现可能是更广泛综合征出现的首发症状，这使小儿泌尿科医生处于影响儿童健康的独特位置。某些泌尿生殖系统表现是特定遗传性癌症易感性综合征的特征性表现，可促使进行基因检测并加强对该疾病其他特征的监测。在其他情况下，对潜在遗传性癌症易感性综合征的了解会改变治疗决策。本综述重点关注影响泌尿生殖系统且小儿泌尿科医生可能会遇到的遗传性癌症易感性综合征。
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