• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Discovering biomarkers of radioresistance in a radiosensitive cancer: a clinical paradox in nasopharyngeal carcinoma.

作者信息

Tan Laura L Y, Chua Melvin L K

机构信息

Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Division of Radiation Oncology, National Cancer Centre Singapore, Singapore, Singapore.

出版信息

Ann Transl Med. 2020 Oct;8(20):1284. doi: 10.21037/atm-20-5405.

DOI:10.21037/atm-20-5405
PMID:33209864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7661868/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d444/7661868/328e221afc1a/atm-08-20-1284-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d444/7661868/328e221afc1a/atm-08-20-1284-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d444/7661868/328e221afc1a/atm-08-20-1284-f1.jpg

相似文献

1
Discovering biomarkers of radioresistance in a radiosensitive cancer: a clinical paradox in nasopharyngeal carcinoma.在一种对放疗敏感的癌症中发现放射抗性生物标志物:鼻咽癌中的临床悖论。
Ann Transl Med. 2020 Oct;8(20):1284. doi: 10.21037/atm-20-5405.
2
Knockdown of Annexin A1 Enhances Radioresistance and Inhibits Apoptosis in Nasopharyngeal Carcinoma.膜联蛋白A1的敲低增强鼻咽癌的放射抗性并抑制其凋亡。
Technol Cancer Res Treat. 2018 Jan 1;17:1533034617750309. doi: 10.1177/1533034617750309.
3
A five-variable signature predicts radioresistance and prognosis in nasopharyngeal carcinoma patients receiving radical radiotherapy.一种五变量特征可预测接受根治性放疗的鼻咽癌患者的放射抗性和预后。
Tumour Biol. 2016 Mar;37(3):2941-9. doi: 10.1007/s13277-015-4139-y. Epub 2015 Sep 27.
4
Reduced RKIP enhances nasopharyngeal carcinoma radioresistance by increasing ERK and AKT activity.RKIP表达降低通过增加ERK和AKT活性增强鼻咽癌的放射抗性。
Oncotarget. 2016 Mar 8;7(10):11463-77. doi: 10.18632/oncotarget.7201.
5
Key radioresistance regulation models and marker genes identified by integrated transcriptome analysis in nasopharyngeal carcinoma.基于转录组整合分析鉴定的鼻咽癌关键放射抵抗调控模型和标记基因。
Cancer Med. 2021 Oct;10(20):7404-7417. doi: 10.1002/cam4.4228. Epub 2021 Aug 25.
6
MiRNA-203 Reduces Nasopharyngeal Carcinoma Radioresistance by Targeting IL8/AKT Signaling.微小RNA-203通过靶向白细胞介素8/蛋白激酶B信号通路降低鼻咽癌的放射抗性
Mol Cancer Ther. 2015 Nov;14(11):2653-64. doi: 10.1158/1535-7163.MCT-15-0461. Epub 2015 Aug 24.
7
MiR-125b Increases Nasopharyngeal Carcinoma Radioresistance by Targeting A20/NF-κB Signaling Pathway.miR-125b 通过靶向 A20/NF-κB 信号通路增加鼻咽癌放射抵抗性。
Mol Cancer Ther. 2017 Oct;16(10):2094-2106. doi: 10.1158/1535-7163.MCT-17-0385. Epub 2017 Jul 11.
8
Integrated analysis of differential miRNA and mRNA expression profiles in human radioresistant and radiosensitive nasopharyngeal carcinoma cells.人鼻咽癌耐辐射细胞与辐射敏感细胞差异 miRNA 和 mRNA 表达谱的综合分析。
PLoS One. 2014 Jan 31;9(1):e87767. doi: 10.1371/journal.pone.0087767. eCollection 2014.
9
CLIC4 regulates radioresistance of nasopharyngeal carcinoma by iNOS after γ-rays but not carbon ions irradiation.CLIC4通过诱导型一氧化氮合酶(iNOS)调节鼻咽癌在γ射线照射后的辐射抗性,但对碳离子照射无此作用。
Am J Cancer Res. 2020 May 1;10(5):1400-1415. eCollection 2020.
10
miR‑182‑5p contributes to radioresistance in nasopharyngeal carcinoma by regulating BNIP3 expression.miR-182-5p 通过调控 BNIP3 表达促进鼻咽癌的放射抵抗。
Mol Med Rep. 2021 Feb;23(2). doi: 10.3892/mmr.2020.11769. Epub 2020 Dec 14.

引用本文的文献

1
SELENBP1 Inhibits the Malignant Progression and Radioresistance of Nasopharyngeal Carcinoma Cells Through the KEAP1-NRF2 Signaling Pathway.SELENBP1通过KEAP1-NRF2信号通路抑制鼻咽癌细胞的恶性进展和放射抗性。
Biochem Genet. 2025 Jul 9. doi: 10.1007/s10528-025-11190-4.
2
Predicting disease progression from the rate of bodyweight change in nasopharyngeal carcinoma patient during radiotherapy.根据鼻咽癌患者放疗期间体重变化率预测疾病进展
Sci Rep. 2025 Mar 3;15(1):7490. doi: 10.1038/s41598-025-88810-x.
3
Characterization of unique pattern of immune cell profile in patients with nasopharyngeal carcinoma through flow cytometry and machine learning.

本文引用的文献

1
Germline Polymorphisms and Length of Survival of Nasopharyngeal Carcinoma: An Exome-Wide Association Study in Multiple Cohorts.生殖系多态性与鼻咽癌生存期:多队列全外显子组关联研究
Adv Sci (Weinh). 2020 Mar 20;7(10):1903727. doi: 10.1002/advs.201903727. eCollection 2020 May.
2
Establishment and Characterization of Humanized Mouse NPC-PDX Model for Testing Immunotherapy.用于测试免疫疗法的人源化小鼠NPC-PDX模型的建立与表征
Cancers (Basel). 2020 Apr 22;12(4):1025. doi: 10.3390/cancers12041025.
3
Necroptosis regulates tumor repopulation after radiotherapy via RIP1/RIP3/MLKL/JNK/IL8 pathway.
通过流式细胞术和机器学习对鼻咽癌患者免疫细胞特征进行分析。
J Cell Mol Med. 2024 Jun;28(12):e18404. doi: 10.1111/jcmm.18404.
4
PKCα is a Potentially Useful Marker for Planning Individualized Radiotherapy for Nasopharyngeal Carcinoma.蛋白激酶Cα是鼻咽癌个体化放疗计划中一个潜在有用的标志物。
Cancer Manag Res. 2021 Mar 17;13:2557-2566. doi: 10.2147/CMAR.S289421. eCollection 2021.
细胞程序性坏死调控放疗后肿瘤细胞再增殖及其机制研究
J Exp Clin Cancer Res. 2019 Nov 9;38(1):461. doi: 10.1186/s13046-019-1423-5.
4
MLKL is a potential prognostic marker in gastric cancer.混合谱系激酶结构域样蛋白(MLKL)是胃癌潜在的预后标志物。
Oncol Lett. 2019 Oct;18(4):3830-3836. doi: 10.3892/ol.2019.10687. Epub 2019 Jul 29.
5
Management of locally recurrent nasopharyngeal carcinoma.局部复发性鼻咽癌的治疗管理。
Cancer Treat Rev. 2019 Sep;79:101890. doi: 10.1016/j.ctrv.2019.101890. Epub 2019 Aug 21.
6
Patterns of care and treatment outcomes for local recurrence of NPC after definite IMRT-A study by the HKNPCSG.明确调强放疗后鼻咽癌局部复发的治疗模式和治疗效果:来自 HKNPCSG 的研究。
Head Neck. 2019 Oct;41(10):3661-3669. doi: 10.1002/hed.25892. Epub 2019 Jul 27.
7
The Association Between the Development of Radiation Therapy, Image Technology, and Chemotherapy, and the Survival of Patients With Nasopharyngeal Carcinoma: A Cohort Study From 1990 to 2012.放疗、影像技术和化疗的发展与鼻咽癌患者生存的关系:一项 1990 年至 2012 年的队列研究。
Int J Radiat Oncol Biol Phys. 2019 Nov 1;105(3):581-590. doi: 10.1016/j.ijrobp.2019.06.2549. Epub 2019 Jul 15.
8
Special section on intensity-modulated radiation therapy for head and neck cancer (IMRT).头颈部癌调强放射治疗(IMRT)特刊
Oral Oncol. 2019 Jan;88:49-50. doi: 10.1016/j.oraloncology.2018.11.018. Epub 2018 Nov 20.
9
RPA1 downregulation enhances nasopharyngeal cancer radiosensitivity via blocking RAD51 to the DNA damage site.RPA1 下调通过阻断 RAD51 到 DNA 损伤部位增强鼻咽癌放射敏感性。
Exp Cell Res. 2018 Oct 15;371(2):330-341. doi: 10.1016/j.yexcr.2018.08.025. Epub 2018 Aug 23.
10
Establishment of a nasopharyngeal carcinoma cell line capable of undergoing lytic Epstein-Barr virus reactivation.建立一个能够发生裂解型 Epstein-Barr 病毒激活的鼻咽癌细胞系。
Lab Invest. 2018 Aug;98(8):1093-1104. doi: 10.1038/s41374-018-0034-7. Epub 2018 May 16.