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脑脓肿作为遗传性出血性毛细血管扩张症患者肺动静脉畸形的一种并发症

Brain Abscess as a Complication of Pulmonary Arteriovenous Malformation in a Patient With Hereditary Hemorrhagic Telangiectasia.

作者信息

Moskatel Leon S, Vo Joslyn N, Nayak Keshav R, Crum-Cianflone Nancy F

机构信息

Department of Internal Medicine, Scripps Mercy Hospital, San Diego, California, USA.

Department of Cardiology, Scripps Mercy Hospital, San Diego, California, USA.

出版信息

Open Forum Infect Dis. 2020 Sep 30;7(11):ofaa467. doi: 10.1093/ofid/ofaa467. eCollection 2020 Nov.

Abstract

is a rare cause of human infections ranging from skin and soft tissue infections to bacteremia. It is particularly known for its association with exposure to dogs. We report an unusual case of a 73-year-old female with a brain abscess caused by who was recently diagnosed with hereditary hemorrhagic telangiectasia and a pulmonary arteriovenous malformation. The patient underwent debridement of the brain abscess followed by a 6-week course of vancomycin and rifampin, after which she made a near complete recovery. This is the first case of a brain abscess in an adult due to in the published literature, and we provide a comprehensive review of the literature of all human infections caused by this pathogen and summarize its clinical manifestations, treatment recommendations, and outcomes.

摘要

是人类感染的罕见病因,范围从皮肤和软组织感染到菌血症。它尤其因与接触狗有关而闻名。我们报告了一例不寻常的病例,一名73岁女性患有脑脓肿,病因是最近被诊断患有遗传性出血性毛细血管扩张症和肺动静脉畸形。患者接受了脑脓肿清创术,随后接受了为期6周的万古霉素和利福平治疗,之后她几乎完全康复。这是已发表文献中首例成人因该菌导致脑脓肿的病例,我们对该病原体引起的所有人类感染的文献进行了全面综述,并总结了其临床表现、治疗建议和结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d3c/7652099/1ccdb1c95544/ofaa467_fig1.jpg

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