Department of Pediatrics, Institute of Allergy, Institute for Immunology and Immunological Diseases, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
Severance Hospital, Seoul, Korea.
J Asthma. 2022 Apr;59(4):739-745. doi: 10.1080/02770903.2020.1845724. Epub 2020 Nov 19.
Evaluation of airway inflammation and dysfunction is important in management of allergic rhinitis (AR) since AR is a risk factor for developing asthma. Theoretical nonlinear modeling of exhaled nitric oxide (NO) has revealed extended flow-independent NO parameters that could explain where or how NO metabolism was altered. We aimed to evaluate the association between extended NO parameters and bronchial hyperresponsiveness (BHR) in children with AR.
Exhaled NO was measured in 74 children with AR on the same day they underwent the provocholine challenge test (PCT). Extended NO was measured in three different exhaled flow rates (30, 100, 200 mL/s) and calculated using the Högman-Meriläinen model. We compared the extended NO parameters including bronchial NO (JawNO), airway tissue NO (CawNO), alveolar tissue NO (CaNO), and diffusing capacity of NO (DawNO) between AR with and without BHR groups, and analyzed the correlation between extended NO parameters and the response-dose ratio (RDR) of the PCT. We additionally evaluated 49 respiratory healthy controls.
Among the 74 children with AR, nine showed BHR. JawNO increased more in children with AR than the control group. In children with AR, JawNO was higher in the AR with BHR than without BHR group, and was correlated positively with log RDR ( = 0.373, = .001).
Extended NO analysis including JawNO can be a useful tool for assessing BHR in AR.
评估气道炎症和功能障碍对于过敏性鼻炎（AR）的管理非常重要，因为 AR 是发展为哮喘的危险因素。呼气一氧化氮（NO）的理论非线性建模揭示了扩展的流量无关的 NO 参数，这些参数可以解释 NO 代谢是如何改变的。我们旨在评估 AR 儿童中扩展的 NO 参数与支气管高反应性（BHR）之间的关系。
在 74 名 AR 儿童同一天进行胆碱能激发试验（PCT）时测量其呼出气一氧化氮（NO）。在三种不同呼气流量（30、100、200 mL/s）下测量扩展的 NO，并使用 Högman-Meriläinen 模型进行计算。我们比较了具有和不具有 BHR 组的 AR 儿童的扩展 NO 参数，包括支气管 NO（JawNO）、气道组织 NO（CawNO）、肺泡组织 NO（CaNO）和 NO 扩散能力（DawNO），并分析了扩展 NO 参数与 PCT 的反应剂量比（RDR）之间的相关性。我们还评估了 49 名呼吸道健康对照者。
在 74 名 AR 儿童中，有 9 名出现 BHR。与对照组相比，AR 儿童的 JawNO 增加更多。在 AR 儿童中，JawNO 在 AR 合并 BHR 组高于无 BHR 组，并且与 log RDR 呈正相关（ = 0.373， = .001）。
包括 JawNO 在内的扩展 NO 分析可以成为评估 AR 中 BHR 的有用工具。
