绿茶摄入对健康受试者塞利洛尔药代动力学的影响。
Impact of green tea intake on the pharmacokinetics of celiprolol in healthy subjects.
出版信息
Int J Clin Pharmacol Ther. 2021 Mar;59(3):198-201. doi: 10.5414/CP203795.
OBJECTIVE
To assess the effect of green tea intake on the pharmacokinetics of the β-blocker celiprolol.
MATERIALS AND METHOD
In an open-label crossover study, 3 healthy subjects were given water or a green tea beverage daily for 3 days. On day 4, each subject received a single oral dose of 200 mg celiprolol with water or green tea. Serum and urinary concentrations of celiprolol were measured for up to 24 hours.
RESULTS
Green tea intake decreased the area under the serum concentration-time curve and urinary excretion of celiprolol by 98.6 and 98.0%, respectively.
CONCLUSION
Green tea intake might have a negative impact on the clinical effectiveness of celiprolol.
目的
评估绿茶摄入对β受体阻滞剂塞利洛尔药代动力学的影响。
材料与方法
在一项开放标签的交叉研究中，3 名健康受试者连续 3 天分别每天饮用白开水或绿茶饮料。第 4 天，每位受试者同时服用白开水或绿茶送服单剂量 200mg 塞利洛尔。在 24 小时内，分别检测血清和尿液中塞利洛尔的浓度。
结果
绿茶摄入使塞利洛尔的血清浓度-时间曲线下面积和尿排泄量分别减少了 98.6%和 98.0%。
结论
绿茶摄入可能会对塞利洛尔的临床疗效产生负面影响。
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