Department of Medicine and Nursing, Centre of Biological and Health Sciences, Federal University of Vicosa, Vicosa, Minas Gerais, Brazil.
Department of Veterinary Medicine Vicosa, Centre of Biological and Health Sciences, Federal University of Vicosa, Vicosa, Minas Gerais, Brazil.
Vet Comp Oncol. 2021 Sep;19(3):473-481. doi: 10.1111/vco.12666. Epub 2020 Nov 25.
Feline injection site sarcomas (FISS) are aggressive, with high recurrence and rarely metastasising. The objective of this study was to evaluate, by immunohistochemistry, the expression of oestrogen (ER) and progesterone (PR) receptors in FISS and correlate them with clinical and histopathological aspects. This was a retrospective study with 51 cases of FISS. Immunohistochemistry was performed to detect vimentin, ER, PR and Ki67 expression. Clinical, histopathological and immunohistochemical characteristics were predictor variables and the expression of ER and PR were the dependent ones. Twenty-eight (55%) of the 51 FISS cases were female and 23 (45%) male with 10.7 ± 4.2 years and median tumour size of 3 cm (2.0-5.4). The trunk was the most affected site, with 38 cases (84%). Histological grade III was observed in 57% of the cases, considering differentiation score, necrosis and mitotic index. ER expression, positive in 64% of cases, was associated with the mitotic index (P = .05) and degree of pleomorphism (P = .04). PR was not associated with the variables and 63% of cases were negative for this receptor. Thus, ER expression can affect tumour growth. The knowledge on the FISS hormonal expression is important to clarify the pathophysiological mechanisms. Further studies are needed to predict the value of ER expression in the prognosis of FISS.
猫科动物注射部位肉瘤（FISS）具有侵袭性，复发率高，很少转移。本研究的目的是通过免疫组织化学评估 FISS 中雌激素（ER）和孕激素（PR）受体的表达，并将其与临床和组织病理学方面相关联。这是一项回顾性研究，共纳入了 51 例 FISS 病例。进行免疫组织化学检测以检测波形蛋白、ER、PR 和 Ki67 的表达。临床、组织病理学和免疫组织化学特征是预测变量，而 ER 和 PR 的表达是依赖变量。51 例 FISS 病例中，28 例（55%）为女性，23 例（45%）为男性，平均年龄为 10.7±4.2 岁，肿瘤大小中位数为 3cm（2.0-5.4）。最常受累的部位是躯干，有 38 例（84%）。根据分化评分、坏死和有丝分裂指数，观察到 57%的病例为组织学分级 III。64%的病例 ER 表达阳性，与有丝分裂指数（P=.05）和多形性程度（P=.04）相关。PR 与这些变量无关，63%的病例对此受体呈阴性。因此，ER 表达可能影响肿瘤生长。了解 FISS 的激素表达对于阐明其病理生理机制非常重要。需要进一步研究以预测 ER 表达在 FISS 预后中的价值。
