Eyquem E, de Saint Martin J
Institut Pasteur, Paris.
Rev Fr Transfus Immunohematol. 1987 Oct;30(3):193-221. doi: 10.1016/s0338-4535(87)80087-9.
In general, anti-tetanus vaccination is well tolerated by the recipients, but the repeated inoculations of the vaccine might result in immediate or delayed type of hypersensitivity. The more recent knowledge of the epitopic construction of the toxin defined by tools offered by molecular biology, has helped understand the complexity of humoral and cellular responses as a consequence to vaccination. We have analyzed in this work major antitetanus post-vaccinal manifestations in normal subjects, as well as in patients suffering from different pathological disorders, with regard to immunoglobulin class expression, idiotypic profile, HLA-susceptibility and in vitro cellular responses.
一般来说，破伤风疫苗接种者耐受性良好，但重复接种该疫苗可能会导致速发型或迟发型超敏反应。分子生物学提供的工具对毒素表位结构的最新认识，有助于理解接种疫苗后体液和细胞反应的复杂性。在这项研究中，我们分析了正常受试者以及患有不同病理疾病的患者接种破伤风疫苗后的主要表现，涉及免疫球蛋白类别表达、独特型谱、HLA易感性和体外细胞反应。
