Lu Ke, Du Hai-Tao, Lian Ai-Ling, Su Ying, Wang Feng
Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China.
Department of Centric Operating Room, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China.
Int J Ophthalmol. 2020 Nov 18;13(11):1827-1832. doi: 10.18240/ijo.2020.11.22. eCollection 2020.
Fibroblasts are pleomorphic cells that have a multi-directional effect on organ morphogenesis, tissue homeostasis, and immune response. In fibrotic diseases, fibroblasts synthesize large amounts of extracellular matrix (ECM), leading to scarring and organ failure. Purine-rich box1 (PU.1) is a specific transcription factor of hematopoietic cell and belongs to the E26 transformation specificity (ETS) family. Recently, it was found that the transcription factor PU.1 is an important regulatory factor of the profibrotic gene expression program. TGF-β had been proved to play an important role in many ocular tissue fibrosis diseases, and up-regulated the expression of PU.1 in fibroblasts producing ECM in a Smad-3 dependent manner. We explore the effect of PU.1 on fibrosis of different ocular tissues from this perspective. This article reviews the role of PU.1 and its effects on fibrosis of ocular tissue and other tissues.
成纤维细胞是多形性细胞，对器官形态发生、组织稳态和免疫反应具有多向性作用。在纤维化疾病中，成纤维细胞合成大量细胞外基质（ECM），导致瘢痕形成和器官衰竭。富含嘌呤的盒1（PU.1）是造血细胞的特异性转录因子，属于E26转化特异性（ETS）家族。最近发现，转录因子PU.1是促纤维化基因表达程序的重要调节因子。已证明转化生长因子-β（TGF-β）在许多眼部组织纤维化疾病中起重要作用，并以Smad-3依赖的方式上调产生ECM的成纤维细胞中PU.1的表达。我们从这个角度探讨PU.1对不同眼部组织纤维化的影响。本文综述了PU.1的作用及其对眼部组织和其他组织纤维化的影响。
