Ríos-Lombardía Nicolás, Cicco Luciana, Yamamoto Kota, Hernández-Fernández José A, Morís Francisco, Capriati Vito, García-Álvarez Joaquín, González-Sabín Javier
EntreChem SL, Vivero Ciencias de la Salud. Santo Domingo de Guzmán, Oviedo, 33011, Spain.
Chem Commun (Camb). 2020 Dec 8;56(96):15165-15168. doi: 10.1039/d0cc06584f.
The Meyer-Schuster rearrangement of propargylic alcohols into α,β-unsaturated carbonyl compounds has been revisited by setting up an atom-economic process catalyzed by a deep eutectic solvent FeCl3·6H2O/glycerol. Isomerizations take place smoothly, at room temperature, under air and with short reaction times. The unique solubilizing properties of the eutectic mixture enabled the use of a substrate concentration up to 1.0 M with the medium being recycled up to ten runs without any loss of catalytic activity.
通过建立一种由深共熔溶剂FeCl₃·6H₂O/甘油催化的原子经济过程，对炔丙醇向α,β-不饱和羰基化合物的迈耶-舒斯特重排反应进行了重新研究。异构化反应在室温下、空气中顺利进行，且反应时间短。共熔混合物独特的增溶特性使得底物浓度可达1.0 M，并且该介质可循环使用多达十次而催化活性无任何损失。
