miRNA-122 在川崎病中的诊断价值。

Diagnostic value of miRNA-122 in Kawasaki disease.

机构信息

Department of Pediatrics, Taizhou Jiangyan Hospital of Traditional Chinese Medicine, Taizhou, China.

出版信息

Eur Rev Med Pharmacol Sci. 2020 Nov;24(21):11222-11226. doi: 10.26355/eurrev_202011_23610.

DOI:10.26355/eurrev_202011_23610

PMID:33215440

Abstract

OBJECTIVE

To explore the expression pattern and diagnostic value of microRNA-122 (miRNA-122) in childhood Kawasaki disease (KD).

PATIENTS AND METHODS

A total of 150 children with KD were included in the KD group. During the same period, 150 children with respiratory infection complicated with fever and without myocardial involvement were included in the control group. Serum level of miRNA-122 in children with acute phase of KD and those in the control group was detected. The relationship between serum level of miRNA-122 and clinical features of KD was analyzed by Pearson correlation test. ROC curves were depicted to assess the diagnostic value of miRNA-122 in KD.

RESULTS

Serum level of miRNA-122 was higher in the KD group than controls. In the acute phase of KD, the serum level of miRNA-122 was positively correlated to CRP and NT-proBNP, while negatively correlated to the sodium level. The specificity and sensitivity of miRNA-122 in diagnosing KD was 78.67% and 84.67%, respectively (AUC=0.8861, cut-off value=2.905).

CONCLUSIONS

Serum level of miRNA-122 is significantly enhanced in the acute phase of KD, and highly expressed miRNA-122 is related to systematic inflammation. MiRNA-122 may be used as a diagnostic hallmark of KD.

摘要

目的

探讨 microRNA-122（miRNA-122）在儿童川崎病（KD）中的表达模式及诊断价值。

患者与方法

选择 150 例 KD 患儿为 KD 组，同期选择 150 例发热伴呼吸道感染但无心肌受累的患儿为对照组。检测两组患儿急性期血清 miRNA-122 水平，采用 Pearson 相关检验分析血清 miRNA-122 水平与 KD 临床特征的关系，绘制 ROC 曲线评估 miRNA-122 对 KD 的诊断价值。

结果

KD 组患儿血清 miRNA-122 水平高于对照组。KD 患儿急性期血清 miRNA-122 水平与 CRP、NT-proBNP 呈正相关，与血钠呈负相关。miRNA-122 诊断 KD 的特异度和敏感度分别为 78.67%和 84.67%（AUC=0.8861，cut-off 值=2.905）。