慢性阻塞性肺疾病是否是 2019 冠状病毒病患者不良结局的独立预测因子？
Is chronic obstructive pulmonary disease an independent predictor for adverse outcomes in coronavirus disease 2019 patients?
机构信息
Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou, China.
出版信息
Eur Rev Med Pharmacol Sci. 2020 Nov;24(21):11421-11427. doi: 10.26355/eurrev_202011_23635.
OBJECTIVE
This study aimed to investigate whether pre-existing chronic obstructive pulmonary disease (COPD) was an independent predictor for adverse outcomes in coronavirus disease 2019 (COVID-19) patients.
MATERIALS AND METHODS
We searched electronic databases, including PubMed, Web of Science, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) to screen for eligible articles. A quantitative meta-analysis was performed on the basis of adjusted effect estimates.
RESULTS
We observed that COPD was significantly associated with an increased risk of adverse outcomes in COVID-19 patients, which is based on 18 studies with 26,075 cases reporting adjusted effect estimates (pooled effect = 1.53, 95% confidence interval (CI): 1.29-1.8; I2 = 35.4%, random-effects model).
CONCLUSIONS
We found that pre-existing COPD was an independent risk factor for predicting the adverse outcomes in COVID-19 patients.
目的
本研究旨在探讨是否存在慢性阻塞性肺疾病（COPD）是 2019 年冠状病毒病（COVID-19）患者不良结局的独立预测因素。
材料和方法
我们检索了电子数据库，包括 PubMed、Web of Science、EMBASE 和中国国家知识基础设施（CNKI），以筛选合格的文章。基于调整后的效应估计值进行了定量荟萃分析。
结果
我们观察到 COPD 与 COVID-19 患者不良结局的风险增加显著相关，这是基于 18 项研究，其中有 26075 例病例报告了调整后的效应估计值（合并效应=1.53，95%置信区间[CI]：1.29-1.8；I2=35.4%，随机效应模型）。
结论
我们发现，预先存在的 COPD 是预测 COVID-19 患者不良结局的独立危险因素。
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