光动力疗法在口腔癌前病变和恶性病变中的潜在作用：系统评价。
The potential role of Photodynamic therapy in oral premalignant and malignant lesions: A systematic review.
机构信息
Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania "Luigi Vanvitelli", Naples, Italy.
Interdisciplinary Department of Medicine, University of Bari "A. Moro", Bari, Italy.
出版信息
J Oral Pathol Med. 2021 Apr;50(4):333-344. doi: 10.1111/jop.13139. Epub 2021 Jan 5.
BACKGROUND
Photodynamic therapy (PDT) is considered as a valid treatment option in various branches of dentistry. This systematic review aims to evaluate the usefulness of PDT for treatment of oral premalignant and malignant lesions.
METHODS
The MeSH terms "Photodynamic therapy" and "PDT," in combination with other terms, have been searched by three search engines (PubMed, ISI Web of Science, and the Cochrane Library), and a systematic review has been performed. The Population, Intervention, Comparison, Outcomes, and Study design (PICOS) has been applied as method to outline our study eligibility criteria. Risk of Bias in Non-randomized Studies of Intervention (ROBINS-I) has been performed too.
RESULTS
Initial results were 1513. Definitely, 27 studies met our selection criteria.
CONCLUSIONS
Topical PDT is an easy to perform technique, well-tolerated treatment and it appears to be an effective method with encouraging achievements in the treatment of premalignant and malignant lesions of the soft tissues of the oral cavity; nevertheless more studies are required to integrate the up-to-date experience of this application.
背景
光动力疗法（PDT）被认为是牙科各领域的有效治疗选择。本系统评价旨在评估 PDT 治疗口腔癌前病变和恶性病变的有效性。
方法
通过三个搜索引擎（PubMed、ISI Web of Science 和 Cochrane Library）结合其他术语搜索了“光动力疗法”和“PDT”的 MeSH 术语，并进行了系统评价。采用人群、干预、比较、结局和研究设计（PICOS）作为方法来概述我们的研究纳入标准。还进行了非随机干预研究的偏倚风险（ROBINS-I）评估。
结果
最初的结果是 1513 个。肯定的是，有 27 项研究符合我们的选择标准。
结论
局部 PDT 是一种易于实施的技术，治疗耐受性良好，并且似乎是一种有效的方法，在治疗口腔软组织的癌前病变和恶性病变方面取得了令人鼓舞的成果；然而，需要更多的研究来整合这一应用的最新经验。
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