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超治疗剂量华法林抗凝继发广泛上呼吸道血肿

Extensive Upper Airway Hematoma Secondary to Supratherapeutic Warfarin Anticoagulation.

作者信息

Oyedokun Taofiq Olusegun, Durr Kevin Manuel

机构信息

University of Saskatchewan, Department of Emergency Medicine, Saskatoon, Saskatchewan, Canada.

University of Ottawa, Department of Emergency Medicine, Ottawa, Ontario, Canada.

出版信息

Clin Pract Cases Emerg Med. 2020 Nov;4(4):634-635. doi: 10.5811/cpcem.2020.7.48695.

Abstract

CASE PRESENTATION

A 63-year-old female presented to the emergency department complaining of cough, neck swelling, dysphagia, and dysphonia for two days, with a past medical history of atrial fibrillation managed with warfarin. Investigations revealed a supratherapeutic international normalised ratio (greater than 10). Imaging and endoscopic examination showed an extensive retropharyngeal hematoma with significant mass effect on the airway.

DISCUSSION

A rare but potentially fatal complication of warfarin anticoagulation is upper airway hematoma, with violent coughing described as an inciting cause. Signs of airway compromise necessitate specialist consultation and definitive airway management, while mild cases without airway concerns can be managed conservatively with medical anticoagulation reversal.

摘要

病例介绍

一名63岁女性因咳嗽、颈部肿胀、吞咽困难和声音嘶哑两天就诊于急诊科,既往有房颤病史,正在接受华法林治疗。检查发现国际标准化比值高于治疗范围(大于10)。影像学和内镜检查显示广泛的咽后血肿,对气道有明显的占位效应。

讨论

华法林抗凝治疗罕见但可能致命的并发症是上气道血肿,剧烈咳嗽被认为是诱发原因。气道受压的体征需要专科会诊和确定气道管理方案,而无气道问题的轻症病例可通过药物抗凝逆转进行保守治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9488/7676778/cd93ff974000/cpcem-04-634-g001.jpg

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