Non-coding RNA Group, Functional Genetics and Genomics Lab, Institute of Clinical Physiology (IFC), CNR, Pisa, Italy.
Biochim Biophys Acta Rev Cancer. 2021 Jan;1875(1):188481. doi: 10.1016/j.bbcan.2020.188481. Epub 2020 Nov 17.
One of the main problems with the treatment of metastatic prostate cancer is that, despite an initial positive response, the majority of patients develop resistance and progress. In particular, the resistance to docetaxel, the gold standard therapy for metastatic prostate cancer since 2010, represents one of the main factors responsible for the failure of prostate cancer therapy. According to the present knowledge, different processes contribute to the appearance of docetaxel resistance and non-coding RNA seems to play a relevant role in them. In this review, a comprehensive overview of the miRNA network involved in docetaxel resistance is described, highlighting the pathway/s affected by their activity.
转移性前列腺癌治疗的主要问题之一是，尽管最初有积极的反应，但大多数患者会产生耐药性并进展。特别是，自 2010 年以来，多西紫杉醇（转移性前列腺癌的金标准治疗方法）的耐药性是导致前列腺癌治疗失败的主要因素之一。根据目前的知识，不同的过程有助于多西紫杉醇耐药性的出现，并且非编码 RNA 似乎在其中发挥相关作用。在这篇综述中，描述了涉及多西紫杉醇耐药性的 miRNA 网络的全面概述，强调了受其活性影响的通路/途径。
