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宫颈环扎术应用算法在持续性宫颈缩短病例中,尽管使用了阴道孕酮。

Cervical cerclage application algorithm in continued cervical shortening cases despite vaginal progesterone.

机构信息

Istinye University School of Medicine, Kocaeli Medicalpark Hospital, Department of Obstetrics and Gynecology, Kocaeli, Turkey.

University of Health Sciences, Bagcılar Health and Education Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey.

出版信息

J Gynecol Obstet Hum Reprod. 2021 Mar;50(3):101989. doi: 10.1016/j.jogoh.2020.101989. Epub 2020 Nov 17.

Abstract

OBJECTIVE

The aim of this study is evaluation of pregnancy outcomes of the asymptomatic cases with vaginal progesterone treatment for the 20-30 mm cervical length detected in the transvaginal ultrasonography for fetal abnormality screening and cervical cerclage after cervical length detected <20 mm in weekly cervical length measures; and present the treatment algorithm of progesterone treatment combined with cervical cerclage application.

METHODS

Patients who have the inclusion criteria and cervical length more than 30 mm were categorized as group 1(n = 1948). Group 2 were included patients with cervical length shorter than 30 mm (n = 95). All patients of group 2 started to use vaginal natural progesterone 400 mg/day(n = 87). Pregnancies which progressed with cervical length above 20 mm were continued vaginal progesterone until 34. Gestational week and they were named as group 2A (n = 78). Cervical cerclage were applied to patients with cervical length below than 20 mm measured via transvaginal ultrasonography and they were categorized as group 2B (n = 9).

RESULTS

Excluding 8 cases (8.42 %) which cervical cerclage were applied, 87 patients were administered vaginal progesterone and in 9 cases (10.34 %) cervical shortening were continued despite progesterone treatment. Four out of these nine cases (44.44 %) had cervical cerclage and their deliveries were delayed after 34 th gestational week. Vaginal progesterone treatment prevented cervical shortening in 89.66 % of patients who had cervical length between 20-30 mm and out of these patients.

CONCLUSION

Cervical cerclage application algorithm in continued cervical shortening cases despite vaginal progesterone is beneficial to delay the delivery after 34 th gestational week and related to low complication rate.

摘要

目的

本研究旨在评估阴道孕酮治疗经阴道超声胎儿异常筛查时发现的 20-30mm 宫颈长度无症状病例的妊娠结局,以及在每周宫颈长度测量时发现宫颈长度<20mm 后行宫颈环扎术的病例;并提出孕酮治疗联合宫颈环扎术应用的治疗方案。

方法

符合纳入标准且宫颈长度大于 30mm 的患者归入第 1 组(n=1948)。第 2 组纳入宫颈长度小于 30mm 的患者(n=95)。第 2 组所有患者均开始每天使用阴道天然孕酮 400mg(n=87)。宫颈长度大于 20mm 的妊娠继续阴道用孕酮,直至 34 孕周,命名为第 2A 组(n=78)。经阴道超声测量宫颈长度<20mm 的患者行宫颈环扎术,归入第 2B 组(n=9)。

结果

排除 8 例(8.42%)行宫颈环扎术的患者,87 例患者给予阴道孕酮治疗,9 例(10.34%)患者尽管给予孕酮治疗仍出现宫颈缩短。这 9 例中有 4 例(44.44%)患者行宫颈环扎术,分娩时间延迟至 34 孕周后。在宫颈长度为 20-30mm 的患者中,89.66%的患者经阴道孕酮治疗后宫颈缩短得到预防,这些患者中有 44.44%的患者行宫颈环扎术。

结论

尽管给予阴道孕酮治疗,对继续宫颈缩短的患者应用宫颈环扎术有利于将分娩时间延迟至 34 孕周后,且相关并发症发生率低。

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