Zeng Qiao, Liu Lan, Wen Qingyi, Hu Liping, Zhong Linhua, Zhou Yongjie
Department of Radiology, Jiangxi Cancer Hospital, Nanchang, Jiangxi, China.
Medicine (Baltimore). 2020 Nov 20;99(47):e23264. doi: 10.1097/MD.0000000000023264.
Granular cell tumor of the breast (GCTB) is a benign rare tumor. There are limited reports on its imaging manifestations. GCTB is often misdiagnosed as breast cancer, which results in unnecessary radical mastectomy and excessive treatment. In this article, we have reported a case of a 56-year-old postmenopausal woman with GCTB and highlighted the imaging features to differentiate this rare tumor from breast cancer.
A 56-year-old postmenopausal patient had a chief complaint of a subcutaneous nodule in the upper outer quadrant of her right breast for 2 months. She underwent physical examination, color Doppler ultrasonography, mammography, magnetic resonance, and postoperative pathology.
The final diagnosis was GCTB. The tumor cells were intermingled with the fibrous stroma and normal breast parenchyma and showed positive immunoreaction to S-100, CD68, and neuron-specific enolase.
The patient underwent lumpectomy and sentinel lymph node biopsy.
The patient recovered well after lumpectomy and had no complications during the 2-year follow-up.
There are some important imaging features of GCTB that can be used to distinguish it from breast carcinoma to reduce misdiagnosis.
乳腺颗粒细胞瘤(GCTB)是一种罕见的良性肿瘤。关于其影像学表现的报道有限。GCTB常被误诊为乳腺癌,从而导致不必要的根治性乳房切除术和过度治疗。在本文中,我们报告了一例56岁绝经后女性患GCTB的病例,并强调了将这种罕见肿瘤与乳腺癌区分开来的影像学特征。
一名56岁绝经后患者主诉右乳外上象限皮下结节2个月。她接受了体格检查、彩色多普勒超声检查、乳腺钼靶检查、磁共振检查及术后病理检查。
最终诊断为GCTB。肿瘤细胞与纤维基质和正常乳腺实质混合,对S-100、CD68和神经元特异性烯醇化酶呈阳性免疫反应。
患者接受了肿块切除术和前哨淋巴结活检。
患者肿块切除术后恢复良好,在2年随访期间无并发症。
GCTB有一些重要的影像学特征,可用于将其与乳腺癌区分开来,以减少误诊。