Royal Sussex County Hospital, Eastern Road, Brighton, BN2 5BE, UK.
Surg Oncol. 2011 Jun;20(2):97-105. doi: 10.1016/j.suronc.2009.12.001. Epub 2010 Jan 13.
Granular cell tumour of the breast (GCTB) is a rare tumour which arises from Schwann cells. It is a largely benign tumour but in extremely rare cases can exhibit malignant characteristics. It poses a particular problem as it's characteristics can mimic breast carcinoma clinically, radiologically and macroscopically. This results in the potential misdiagnosis of breast carcinoma and over treatment of patients. Typically GCTBs are benign, solitary lesions but variations include malignant GCTBs, colocalisation with breast malignancies and multicentricity. These tumours can be investigated using mammography, ultrasound and magnetic resonance imaging. However none of these modalities have yet identified any GCTB specific characteristics. On pathological examination they can be identified using both microscopic and immunohistochemical features. The cells have a distinctive granular eosinophilic cytoplasm associated with typical nuclei and abundant lysosomes. Immunohistochemically they are positive for S100 protein, CD68 and neuron specific endolase (NSE). They are treated with wide local excision and while they may reoccur, are associated with a good prognosis.
乳腺颗粒细胞瘤（GCTB）是一种罕见的来源于施万细胞的肿瘤。它是一种基本良性的肿瘤，但在极少数情况下可能表现出恶性特征。它是一个特别的问题，因为它的特征在临床上、影像学上和大体上可以模拟乳腺癌。这导致了乳腺癌的潜在误诊和对患者的过度治疗。通常 GCTBs 是良性的、孤立的病变，但也有变异型，包括恶性 GCTBs、与乳腺恶性肿瘤共存和多中心性。这些肿瘤可以通过乳房 X 线摄影术、超声和磁共振成像进行检查。然而，这些方法都没有确定任何 GCTB 特异性特征。在病理检查中，它们可以通过显微镜和免疫组织化学特征来识别。这些细胞具有独特的颗粒状嗜酸性细胞质，与典型的细胞核和丰富的溶酶体相关。免疫组织化学上，它们对 S100 蛋白、CD68 和神经元特异性烯醇化酶（NSE）呈阳性。它们通过广泛的局部切除进行治疗，虽然可能会复发，但预后良好。
