Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Int J Mol Sci. 2020 Nov 18;21(22):8705. doi: 10.3390/ijms21228705.
The concept that hypertension and chronic kidney disease (CKD) originate in early life has emerged recently. During pregnancy, tryptophan is crucial for maternal protein synthesis and fetal development. On one hand, impaired tryptophan metabolic pathway in pregnancy impacts fetal programming, resulting in the developmental programming of hypertension and kidney disease in adult offspring. On the other hand, tryptophan-related interventions might serve as reprogramming strategies to prevent a disease from occurring. In the present review, we aim to summarize (1) the three major tryptophan metabolic pathways, (2) the impact of tryptophan metabolism in pregnancy, (3) the interplay occurring between tryptophan metabolites and gut microbiota on the production of uremic toxins, (4) the role of tryptophan-derived metabolites-induced hypertension and CKD of developmental origin, (5) the therapeutic options in pregnancy that could aid in reprogramming adverse effects to protect offspring against hypertension and CKD, and (6) possible mechanisms linking tryptophan metabolism to developmental programming of hypertension and kidney disease.
近年来，人们提出了高血压和慢性肾脏病（CKD）起源于生命早期的概念。在妊娠期间，色氨酸对于母体蛋白质合成和胎儿发育至关重要。一方面，妊娠期间色氨酸代谢途径受损会影响胎儿编程，导致成年后代高血压和肾脏病的发育编程。另一方面，色氨酸相关干预措施可能作为重编程策略来预防疾病发生。在本综述中，我们旨在总结（1）三种主要的色氨酸代谢途径，（2）妊娠期间色氨酸代谢的影响，（3）色氨酸代谢物与肠道微生物群之间相互作用对尿毒症毒素产生的影响，（4）色氨酸衍生代谢物诱导的高血压和 CKD 的发育起源的作用，（5）妊娠期间可用于重编程不利影响以保护后代免受高血压和 CKD 影响的治疗选择，以及（6）将色氨酸代谢与高血压和肾脏病的发育编程联系起来的可能机制。
Zotero 插件
