Boghaert A, Haesaert G, Mourisse P, Verlinden M
O. L. Vrouw Hospital, Aalst, Belgium.
Acta Anaesthesiol Belg. 1987;38(3):195-9.
The effect of 4 mg of the gastrointestinal motility enhancing agent cisapride on postoperative ileus was compared with that of a placebo in 53 patients who had undergone various types of surgery. They received one i.v. injection of the double-blind medication, or two if no distinct flatus occurred within an hour after the first injection. The placebo response was very limited; borborygmi or flatus did not occur in more than 12% of the patients not even after the second injection. Cisapride was significantly effective: bowel sounds were present in 43% and 50% within 1 hour after the first and second injection of 4 mg, respectively, and flatus in 36% and 43%. The recognition that colon inactivity probably is the major determinant of the ileus, may be indicative of a substantial relative impact of cisapride's stimulating effects on colon motility.
在53例接受了各类手术的患者中，对比了4毫克胃肠动力增强剂西沙必利与安慰剂对术后肠梗阻的影响。他们接受了一次静脉注射双盲药物，如果在首次注射后一小时内未出现明显的肠胃气胀，则再注射一次。安慰剂的效果非常有限；即使在第二次注射后，超过12%的患者仍未出现肠鸣音或肠胃气胀。西沙必利显著有效：在首次和第二次注射4毫克药物后1小时内，分别有43%和50%的患者出现肠鸣音，36%和43%的患者出现肠胃气胀。认识到结肠不活动可能是肠梗阻的主要决定因素，这可能表明西沙必利对结肠动力的刺激作用具有相当大的相对影响。
