College of Pharmacy and Chemistry, Dali University, Dali, China.
Department of Pharmacy, 920th Hospital of Joint Logistics Support Force, Kunming, China.
J Cosmet Dermatol. 2021 Jul;20(7):2359-2368. doi: 10.1111/jocd.13857. Epub 2020 Dec 3.
Vitiligo is a common pigmentary skin disorder, and genetic factors were acknowledged to be greatly associated with the pathogenesis of this disease. Recently, increasing studies investigated the associations of methylenetetrahydrofolate reductase (MTHFR) rs1801131 and rs1801133 polymorphisms with risks of vitiligo, but the results still remained controversial.
The current meta-analysis was conducted to further evaluate the association of MTHFR polymorphisms with risk of vitiligo.
Eligible studies were searched in PubMed, EMBASE, Cochrane library, Chinese National Knowledge Infrastructure (CNKI), Technology of Chongqing (VIP), and Wan Fang Database until October 2020. All analyses were carried out using the Review Manager 5.3 software.
A total of 6 studies that involved MTHFR rs1801131 and/or rs1801133 polymorphism were finally included, which enrolled 3599 participants. Our results showed that no correlations were found between MTHFR rs1801131, rs1801133 polymorphisms and vitiligo risks in overall group. However, subgroup analysis revealed that rs1801131 polymorphism was significantly associated with increased vitiligo risk in the allelic (C vs A: OR = 1.15, 95% CI = 1.02-1.29, P = .02) and homozygous models (CC vs AA: OR = 1.48, 95% CI = 1.10-2.01, P = .01) in Asian population and that the rs1801133 polymorphism was significantly associated with decreased vitiligo risk in the allelic model (T vs C: OR = 0.82, 95% CI = 0.74-0.92, P = .0005) also in Asian population.
This meta-analysis confirmed the associations of MTHFR rs1801131 and rs1801133 polymorphisms with vitiligo risks and provided comprehensive insight into the pathogenesis of vitiligo.
白癜风是一种常见的色素性皮肤疾病，遗传因素被认为与该病的发病机制密切相关。最近，越来越多的研究探讨了亚甲基四氢叶酸还原酶（MTHFR）rs1801131 和 rs1801133 多态性与白癜风风险的关联，但结果仍存在争议。
本荟萃分析旨在进一步评估 MTHFR 多态性与白癜风风险的关联。
检索 PubMed、EMBASE、Cochrane 图书馆、中国知网（CNKI）、维普及万方数据库，检索时限均从建库至 2020 年 10 月，采用 Review Manager 5.3 软件进行数据分析。
最终纳入了 6 项研究，共涉及 MTHFR rs1801131 和/或 rs1801133 多态性，共纳入 3599 名参与者。结果显示，MTHFR rs1801131 和 rs1801133 多态性与总体人群的白癜风发病风险无关。然而，亚组分析显示，rs1801131 多态性在亚洲人群中与白癜风发病风险增加相关，等位基因（C 对 A：OR=1.15，95%CI=1.02-1.29，P=0.02）和纯合子模型（CC 对 AA：OR=1.48，95%CI=1.10-2.01，P=0.01）；rs1801133 多态性在亚洲人群中与白癜风发病风险降低相关，等位基因模型（T 对 C：OR=0.82，95%CI=0.74-0.92，P=0.0005）。
本荟萃分析证实了 MTHFR rs1801131 和 rs1801133 多态性与白癜风发病风险相关，并为白癜风的发病机制提供了全面的见解。
