Farhood A I, Morris J H, Bieber F R
Department of Pathology, Brigham & Women's Hospital, Boston, MA 02115.
Am J Med Genet. 1987 Aug;27(4):977-82. doi: 10.1002/ajmg.1320270428.
In this report, we correlate the clinical and morphologic features of bilateral choroid plexus cysts in three fetuses. These cysts were detected as incidental findings during sonography at 18 to 20 weeks gestation before elective abortion. Two fetuses were normal; the third had trisomy 18. All cysts were present bilaterally in the posterior horns of the lateral ventricles and ranged from 0.5 cm to 1.0 cm in diameter. The walls were translucent, and the cavities were filled with clear serous fluid, except for the left cyst in the third fetus, which was hemorrhagic. The cysts were surrounded by the loose stroma of the choroid plexus. We believe that the formation of these cysts is related to the histogenesis of the choroid plexus. Although such cysts have now been described by sonographers in several fetuses with chromosomal anomalies, this association may reflect ascertainment bias. At this time, we therefore advise caution in interpreting sonographic evidence of isolated choroid plexus cysts as anomalous.
在本报告中，我们对3例胎儿双侧脉络丛囊肿的临床和形态学特征进行了相关性分析。这些囊肿是在妊娠18至20周进行超声检查时作为偶然发现的，当时是在选择性流产前。2例胎儿正常；第3例患有18三体综合征。所有囊肿均双侧位于侧脑室后角，直径在0.5厘米至1.0厘米之间。囊肿壁半透明，腔内充满清亮浆液，除第3例胎儿左侧囊肿为出血性外。囊肿被脉络丛的疏松间质所围绕。我们认为这些囊肿的形成与脉络丛的组织发生有关。尽管超声检查人员现已在数例患有染色体异常的胎儿中描述了此类囊肿，但这种关联可能反映了确诊偏倚。因此，此时我们建议在将孤立性脉络丛囊肿的超声证据解释为异常情况时应谨慎。
