Servicio de Dermatología, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, España.
Servicio de Dermatología, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, España.
Actas Dermosifiliogr (Engl Ed). 2021 Apr;112(4):339-344. doi: 10.1016/j.ad.2020.11.007. Epub 2020 Nov 19.
Prurigo nodularis is a chronic inflammatory skin disease characterized by highly pruritic nodular lesions that cause constant itching and scratching and significant quality-of-life impairment. It has been described in a range of conditions, including skin diseases (mainly atopic dermatitis) and metabolic, neurological, and psychiatric disorders. The pathophysiological mechanisms are largely unknown. Various modalities of phototherapy have been described as appropriate and safe treatments for achieving clinical control and alleviating symptoms. In this article, we describe our experience with phototherapy in patients with prurigo nodularis.
Retrospective observational study of patients who received their first cycle of phototherapy to treat prurigo nodularis between March 2011 and October 2019. Information was collected on epidemiological and clinical characteristics, concomitant treatments, type and duration of phototherapy, maximum dose reached, and response to treatment.
We studied 44 patients (30 women and 14 men) with a median age of 65.5years. The most common form of phototherapy used was narrowband UV-B phototherapy (34 cycles, 77.27%) followed by a combination of UV-B and UV-A phototherapy (8 cycles). Response to treatment was considered satisfactory (clearance rate of ≥75%) in 24 patients (55.4%).
Phototherapy is a suitable treatment for prurigo nodularis in a considerable proportion of patients. It can be used as monotherapy or combined with other treatments.
结节性痒疹是一种慢性炎症性皮肤病，其特征为高度瘙痒的结节性病变，导致持续瘙痒和搔抓，显著影响生活质量。它已在多种疾病中被描述，包括皮肤病（主要为特应性皮炎）以及代谢、神经和精神障碍。其病理生理机制在很大程度上尚不清楚。各种光疗方式已被描述为可用于实现临床控制和缓解症状的合适且安全的治疗方法。本文描述了我们应用光疗治疗结节性痒疹患者的经验。
回顾性观察研究了 2011 年 3 月至 2019 年 10 月期间首次接受光疗治疗结节性痒疹的患者。收集了患者的流行病学和临床特征、伴随治疗、光疗类型和持续时间、最大剂量以及治疗反应等信息。
共纳入 44 例患者（30 名女性和 14 名男性），中位年龄为 65.5 岁。最常使用的光疗形式是窄谱 UV-B 光疗（34 个周期，77.27%），其次是 UV-B 联合 UV-A 光疗（8 个周期）。24 例患者（55.4%）的治疗反应被认为是满意的（清除率≥75%）。
光疗是结节性痒疹患者的一种合适治疗方法。它可以单独使用或与其他治疗方法联合使用。
