The University of Sydney, Faculty of Medicine and Health, School of Pharmacy, Sydney, NSW, Australia.
School of Computer Science, University of Sydney, Sydney, NSW, Australia.
Int J Med Inform. 2021 Jan;145:104325. doi: 10.1016/j.ijmedinf.2020.104325. Epub 2020 Nov 4.
For patients requiring admission to the Intensive Care Unit (ICU), transfers of care (TOC) during admission to and discharge from the ICU are particularly high-risk periods for medication errors. In the Australian setting, commonly general wards and the ICU do not share an integrated Electronic Medical ecord (EMR) and specifically an Electronic Medication Management System (EMMS) as part of the EMR.
To evaluate the effect of a hospital wide integrated EMMS on medication error rates during ICU admission and at TOC.
A 6-month historical control study was performed before and after implementation of the EMMS in the ICU of a tertiary hospital. Prescribing errors detected by pharmacists in the study period were divided into phase 1, (pre-EMMS, 6months), phase 2 (3 months post implementation after shakedown stage) and phase 3 (next 3 months of post implementation). They were categorized as prescribing error types under system or clinical intervention. Chi square statistics and interrupted time series analysis were used to determine if there was significant change in the proportion of patients who had an error at TOC during each phase. Logistics regression was used to determine the relationship between the dependent (error type) and the independent variable (study phase) for errors that occurred during TOC.
Errors occurred during TOC in 42 %, 64 % and 19 % of patients in phase 1, 2 and 3 respectively. There was a significant decline in the proportion of patients with an error between phase 1 and 3 (p < 0.01). During a patient's ICU admission, at least one medication error occurred in 28.3 %, 62.6 % and 25.1 % in phase 1, 2 and 3 respectively. Besides procedural errors, the likelihood of an error occurring was greatest in phase 1, compared to phase 2 and 3 across system-related error categories.
Medication errors during TOC reduced following implementation of the integrated ICU EMMS. EMMS safety features facilitated reduced system related prescribing errors as well as the severity of errors made.
对于需要入住重症监护病房(ICU)的患者,在入住和离开 ICU 期间的护理交接(TOC)是发生药物错误的高风险时期。在澳大利亚,普通病房和 ICU 通常没有共享集成的电子病历(EMR),特别是没有共享 EMR 中的电子药物管理系统(EMMS)。
评估 ICU 内广泛采用集成 EMMS 对 TOC 期间药物错误率的影响。
在一家三级医院的 ICU 中实施 EMMS 之前和之后进行了为期 6 个月的历史对照研究。研究期间,药剂师发现的处方错误分为三个阶段:阶段 1(实施前,6 个月)、阶段 2(实施后稳定阶段的 3 个月)和阶段 3(实施后 3 个月)。它们根据系统或临床干预分为处方错误类型。使用卡方检验和中断时间序列分析来确定在每个阶段,在 TOC 期间发生错误的患者比例是否有显著变化。使用逻辑回归来确定在 TOC 期间发生的错误中,依赖变量(错误类型)与独立变量(研究阶段)之间的关系。
在 TOC 期间,第 1、2 和 3 阶段分别有 42%、64%和 19%的患者发生错误。与第 1 阶段相比,第 1 阶段和第 3 阶段之间患者发生错误的比例有显著下降(p<0.01)。在 ICU 住院期间,第 1、2 和 3 阶段分别有 28.3%、62.6%和 25.1%的患者至少发生一次药物错误。除了程序错误外,与第 2 阶段和第 3 阶段相比,第 1 阶段发生系统相关错误的可能性最大。
实施 ICU 集成 EMMS 后,TOC 期间的药物错误减少。EMMS 的安全功能有助于减少系统相关的处方错误,并降低错误的严重程度。