用西帕胺每日一次治疗轻至中度高血压：一项对照研究。
Once daily treatment of mild to moderate hypertension with xipamid: a controlled study.
作者信息
Weber J C, Bird H, Cosh J, Davies P S, Dixon A S, Lister J, Petts H V, Prichard B N, Raftery E B
出版信息
Br J Clin Pharmacol. 1977 Jun;4(3):283-8. doi: 10.1111/j.1365-2125.1977.tb00713.x.
A double-blind, placebo controlled, crossover trial of 20 and 40 mg of xipamid once daily in the treatment of mild to moderate hypertension is reported and some of the difficulties and pitfalls of multicentre trials of this type are described. 2 Both doses were significantly more effective in reducing the blood pressure than the placebo and neither was superior to the other. Both produced some potassium loss. Xipamid acted for at least 22 h and was effective in up to 83% of the patients. 3 Further trials are suggested to investigate the activity of a lower dose than 20 mg.
本文报道了一项双盲、安慰剂对照、交叉试验，该试验针对轻度至中度高血压患者，每日服用一次20毫克和40毫克的希帕胺，并描述了此类多中心试验的一些困难和陷阱。两种剂量在降低血压方面均比安慰剂显著有效，且二者效果相当。二者均导致了一定程度的钾流失。希帕胺的作用至少持续22小时，对高达83%的患者有效。建议进行进一步试验，以研究低于20毫克剂量的活性。
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