Bonaduce D, Ferrara N, Petretta M, Canonico V, Romango E, Rengo F
Curr Med Res Opin. 1981;7(4):247-52. doi: 10.1185/03007998109114270.
The effectiveness of a new potent diuretic, xipamide, was evaluated in the treatment of patients with mild to moderate essential hypertension. The effects of daily doses of 40 mg xipamide were compared with those of 100 mg chlorthalidone with respect to systolic and diastolic blood pressure, using a double-blind crossover design. Patients received each drug for 6 weeks, the order of treatments being at random and the periods being separated by a 'washout' period of 7 days. The results showed that xipamide was as effective as chlorthalidone in controlling blood pressure, both in the upright and supine positions, and when administered after chlorthalidone produced a further reduction. No such further reduction occurred when chlorthalidone was given after xipamide. Serum electrolyte changes induced by the two diuretics were comparable. Both drugs were well tolerated and caused few side-effects.
对一种新型强效利尿剂西帕胺治疗轻至中度原发性高血压患者的疗效进行了评估。采用双盲交叉设计，比较了每日40毫克西帕胺剂量与100毫克氯噻酮剂量对收缩压和舒张压的影响。患者每种药物服用6周，治疗顺序随机，各阶段间隔7天的“洗脱期”。结果显示，西帕胺在控制直立位和仰卧位血压方面与氯噻酮同样有效，且在氯噻酮之后给药时能进一步降低血压。而在西帕胺之后给予氯噻酮则不会出现这种进一步降低的情况。两种利尿剂引起的血清电解质变化相当。两种药物耐受性良好，副作用较少。
