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2000-2016 年期间成人急性髓系白血病患者的生存时间变化:一项丹麦基于人群的研究。

Temporal changes in survival among adult patients with acute myeloid leukaemia in the period 2000-2016: a Danish population-based study.

机构信息

Department of Hematology, Aalborg University Hospital, Aalborg, Denmark.

Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

出版信息

Br J Haematol. 2021 May;193(3):482-487. doi: 10.1111/bjh.17213. Epub 2020 Nov 21.

Abstract

In the present study, we quantify the progress in overall survival (OS) during the period 2000-2016 among Danish patients with acute myeloid leukaemia (AML). This population-based study, including 3820 adult patients with AML, demonstrates a significantly improved OS over time with the 2-year age-standardised OS increasing from 22% in 2002 to 31% in 2016. The improvement in OS was exclusively seen in patients with AML aged ≥50 years, with absolute improvements in 2-year OS from 2002 to 2016 of ≥10% among patients aged 50-75 years and a small absolute increase in those aged >75 years.

摘要

在本研究中,我们定量评估了 2000 年至 2016 年期间丹麦急性髓系白血病(AML)患者的总生存期(OS)进展情况。这项基于人群的研究纳入了 3820 例成年 AML 患者,结果显示 OS 随时间显著改善,2 年年龄标准化 OS 从 2002 年的 22%增加到 2016 年的 31%。OS 的改善仅见于年龄≥50 岁的 AML 患者,年龄在 50-75 岁的患者 2 年 OS 的绝对改善≥10%,年龄>75 岁的患者略有增加。

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