边界争端：在发炎的皮肤中，肥大细胞扩张并破坏稳定的克隆区域。
Boundary Disputes: In Inflamed Skin, Mast Cells Expand and Disorganize Stable Clonal Territories.
机构信息
Department of Dermatology, University of California San Diego, San Diego, California, USA.
Department of Dermatology, University of California San Diego, San Diego, California, USA.
出版信息
J Invest Dermatol. 2020 Dec;140(12):2329-2331. doi: 10.1016/j.jid.2020.04.032.
Skin mast cells (MCs) are distinct from other MCs, and for years, we have tried to understand their origin and peculiarities. A recent study demonstrated that during development, MCs enter the skin from the yolk sac and embryonic liver and are later mixed with cells originating from the bone marrow. A report from Weitzmann et al. (2020) shows that MCs or their precursors occupy distinct areas in the fetal period and that they and their progeny maintain these geographic distributions throughout life. These stable clonal territories are altered only by the arrival of bone marrow‒derived MCs during inflammation.
皮肤肥大细胞（MCs）与其他 MCs 不同，多年来，我们一直试图了解其起源和特性。最近的一项研究表明，在发育过程中，MC 从卵黄囊和胚胎肝脏进入皮肤，随后与源自骨髓的细胞混合。Weitzmann 等人的报告。（2020 年）表明，MC 或其前体细胞在胎儿期占据不同的区域，它们及其后代在整个生命周期中保持这些地理分布。只有在炎症期间骨髓衍生的 MC 到达时，这些稳定的克隆性区域才会发生改变。
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